摘要
目的 分析血清中白细胞介素-6(IL-6)和降钙素原(PCT)水平与急性淋巴细胞白血病(ALL)患儿预后的相关性。方法 选取88例ALL患儿(作为观察组)和57例非恶性血液病患儿(作为对照组),采用酶联免疫吸附试验检测血清IL-6水平,采用免疫荧光层析法检测血清PCT水平。比较不同临床特征ALL患儿血清IL-6和PCT水平,分析血清IL-6和PCT水平与ALL患儿预后的关系。结果 观察组患儿血清IL-6、PCT水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。不同Risk分层、白细胞计数、血红蛋白水平、血小板计数、原始细胞比例的ALL患儿血清IL-6、PCT水平比较,差异均有统计学意义(P﹤0.01)。以血清IL-6水平22.17 pg/ml为临界值将88例ALL患儿分为IL-6高表达组(n=52,≥22.17 pg/ml)和IL-6低表达组(n=36,﹤22.17 pg/ml),IL-6高表达组ALL患儿的中位无进展生存期(PFS)为12个月(95%CI:10.2~17.4个月),明显短于IL-6低表达组患儿的19个月(95%CI:13.5~22.9个月),差异有统计学意义(P﹤0.01)。以血清PCT水平25.38 ng/ml为临界值,将88例ALL患儿分为PCT高表达组(n=54,≥25.38 ng/ml)和PCT低表达组(n=34,﹤25.38 ng/ml),PCT高表达组ALL患儿的中位PFS为16个月(95%CI:12.1~18.6个月),明显短于PCT低表达组患儿的20个月(95%CI:15.4~24.4个月),差异有统计学意义(P﹤0.01)。结论 ALL患儿血清IL-6和PCT水平升高,IL-6和PCT可能参与了ALL的发生发展过程,并对ALL患儿的预后有一定的预测价值。
Objective To analyze the relationship between serum interleukin-6(IL-6) and procalcitonin(PCT) levels and prognosis in children with acute lymphoblastic leukemia(ALL).Method Eighty-eight children with ALL(as the observation group) and 57 children with non-malignant hematological diseases(as the control group) were selected.The serum IL-6 level was detected by enzyme-linked immunosorbent assay,and the serum PCT level was detected by immunofluorescence chromatography.The serum IL-6 and PCT levels in children with ALL with different clinical characteristics were compared,and the relationship between serum IL-6 and PCT levels and the prognosis of children with ALL was analyzed.Result The serum levels of IL-6 and PCT in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.01).There were significant differences in serum IL-6and PCT levels in children with ALL with different risk stratification,white blood cell count,hemoglobin level,platelet count,and blast cell ratio(P<0.01).Eighty-eight children with ALL were divided into IL-6 high-expression group(n=52,≥22.17 pg/ml) and IL-6 low-expression group(n=36,<22.17 pg/ml) based on the serum IL-6 level of 22.17 pg/ml.The median progression-free survival(PFS) of the children with ALL in the high IL-6 expression group was 12 months(95%CI:10.2-17.4 months),which was shorter than that in the low IL-6 expression group by 19 months(95%CI:13.5-22.9 months),the difference was statistically significant(P<0.05).Eighty-eight children with ALL were divided into PCT high-expression group(n=54,≥25.38 ng/ml) and PCT low-expression group(n=34,<25.38 ng/ml) with serum PCT level of 25.38 ng/ml as the cut value.The median PFS of children with ALL in the PCT high-expression group was 16 months(95%CI:12.1-18.6 months),which was shorter than that in the PCT low-expression group by 20 months(95%CI:15.4-24.4 months),the difference was statistically significant(P<0.05).Conclusion The levels of serum IL-6 and PCT ar
作者
赵凯
蔡莉莉
王根杰
ZHAO Kai;CAI Lili;WANG Genjie(Department of Clinical Laboratory,First People’s Hospital of Shangqiu,Shangqiu 476100,He’nan,China;Department of Blood Transfusion,First People’s Hospital of Shangqiu,Shangqiu 476100,He’nan,China;Department of Hematology,First People’s Hospital of Shangqiu,Shangqiu 476100,He’nan,China)
出处
《癌症进展》
2022年第15期1587-1589,1593,共4页
Oncology Progress
