摘要
目的:通过Excel软件计算非房室模型药动学参数并进行生物等效性分析。方法:根据药动学参数意义,利用一系列函数公式在Excel软件完成药动学参数、90%置信区间和个体内变异计算并进行多因素方差分析。将结果与Phoenix WinNolin软件的计算结果进行对比。结果:使用Excel软件进行非房室模型的药动学参数计算和生物等效性分析,结果与Phoenix WinNolin软件的计算结果一致。结论:可以通过Excel软件实现非房室模型药动学参数的计算和生物等效性分析,且结果准确。
Objective:To calculate the pharmacokinetic parameters of non-atrioventricular model by Excel software and analyze the bioequivalence.Methods:To master the significance of pharmacokinetic parameters,and to complete the calculation of pharmacokinetic parameters,90%confidence interval and within-individual variation by using a series of functional formulas in Excel software,and to carry out multivariate analysis of variance.The results are compared with those calculated by Phoenix WinNolin software.Results:The pharmacokinetic parameters and bioequivalence of non-atrioventricular model were calculated by Excel software,and the results were consistent with those calculated by Phoenix WinNolin software.Conclusion:The calculation of pharmacokinetic parameters and bioequivalence analysis of non-atrioventricular model can be realized by Excel statistical software,and the results are accurate.
作者
姚青
刘莹
王晓芳
高宁
王苗
YAO Qing;LIU Ying;WANG Xiao-fang;GAO Ning;WANG Miao(Leadingpharm Medical Technology Development Co.,Ltd.,Beijing 100094,China)
出处
《中国药物评价》
2022年第4期331-337,共7页
Chinese Journal of Drug Evaluation
