摘要
目的分析清远区儿童珠蛋白生成障碍性贫血发生情况及基因检测的结果。方法研究总共纳入3430例观察对象,均是清远市妇幼保健院2019年7月—2021年6月收治的珠蛋白生成障碍性贫血患儿,所有患儿均进行珠蛋白生成障碍性贫血基因检查。观察并分析珠蛋白生成障碍性贫血发生率以及相应的基因检测结果情况。结果3430例患儿中,珠蛋白生成障碍性贫血的阳性率为74.29%(2548/3430)。α-珠蛋白生成障碍性贫血的占比为78.1%(1990/2548),β-珠蛋白生成障碍性贫血的占比为21.90%(558/2548),其差异有统计学意义(P<0.05)。结论清远区儿童珠蛋白生成障碍性贫血的发生率较高,α-珠蛋白生成障碍性贫血与β-珠蛋白生成障碍性贫血是主要的贫血类型。基因检测用于儿童珠蛋白生成障碍性贫血的检测效果理想,为珠蛋白生成障碍性贫血的诊断与防治提供了参考依据,临床可进一步推广应用。
Objective To analyze the occurrence of dysglobinogenesis anemia in children in Qingyuan district and the results of genetic testing.Methods A total of 3430 observation subjects were included in this study,all of whom were children with anemia admitted to our hospital from July 2019 to June 2021.All children underwent thalassemia genetic testing.Observed the occurrence of dysglobinogenesis anemia and the results of genetic testing.Results Among the 3430 children,the positive rate of dysglobinogenesis anemia was 74.29%(2548/3430).The proportion ofα-dysglobinogenesis anemia was 78.1%(1990/2548),and the proportion ofβ-dysglobinogenesis anemia was 21.90%(558/2548),and the difference was statistically significant(P<0.05).Conclusion The incidence of dysglobinogenesis anemia in children in Qingyuan district is relatively high,andα-dysglobinogenesis anemia andβ-dysglobinogenesis anemia are the main types.Genetic testing has ideal results for the detection of dysglobinogenesis anemia in children,provides a reference for the diagnosis and prevention of dysglobinogenesis anemia,and can be further promoted and applied in clinical practice.
作者
罗炼
吴文华
LUO Lian;WU Wenhua(Department of Pediatrics,Maternal and Child Health Hospital of Qingyuan City,Qingyuan Guangdong 511500,China)
出处
《中国卫生标准管理》
2022年第14期34-38,共5页
China Health Standard Management
