摘要
目的探讨活血通脉方溻渍对糖尿病周围神经病变的影响。方法选取2019年6月至2020年9月北京中医药大学东直门医院周围血管科收治的糖尿病周围神经病变患者60例,根据随机数字表法将其分为治疗组和对照组,每组30例。除糖尿病基础治疗及口服甲钴胺外,对照组给予安慰剂溻渍治疗,治疗组给予活血通脉方溻渍治疗,疗程为28 d。比较两组临床疗效;治疗前后腓总神经和胫神经感觉传导速度(SNCV)、运动传导速度(MNCV);比较两组治疗前后脑源性神经营养因子(BDNF)、髓鞘碱性蛋白(MBP)含量。结果治疗组临床疗效优于对照组(P<0.05)。治疗后,两组腓总神经和胫神经SNCV、MNCV较治疗前升高,且治疗组高于对照组(P<0.05)。治疗后,两组血清BDNF水平较治疗前升高,MBP水平较治疗前下降(P<0.05);治疗组血清BDNF水平高于对照组,MBP水平低于对照组(P<0.05)。治疗过程中未出现明显不良反应。结论活血通脉方溻渍能提高糖尿病周围神经病变患者的神经传导速度,改善患者的临床症状,其作用机制可能与增加BDNF含量,降低MBP含量有关。
Objective To observe the effect of Huoxue Tongmai Decoction soaking in the treatment of diabetic peripheral neuropathy.Methods Sixty patients with diabetic peripheral neuropathy in Department of Peripheral Vascular,Dongzhimen Hospital from June 2019 to September 2020 were selected.They were divided into treatment group and control group according to the random number table method,with 30 cases in each group.In addition to the basic treatment of diabetes and oral administration of Mecobalamin,control group was treated with placebo soaking,and treatment group was treated with Huoxue Tongmai Decoction soaking.The treatment course lasted for 28 days.The curative effect of two groups was compared;sensory nerve conduction velocity(SNCV)and motor nerve conduction velocity(MNCV)of common peroneal nerve and tibial nerve were observed before and after treatment;the contents of brain derived neurotrophic factor(BDNF)and myelin basic protein(MBP)of two groups were observed before and after treatment.Results The clinical efficacy of treatment group was better than control group(P<0.05).After treatment,SNCV and MNCV of common peroneal nerve and tibial nerve in two groups were higher than those before treatment,and those in the treatment group were higher than those in the control group(P<0.05).After treatment,the level of serum BDNF increased and the level of MBP decreased in both groups(P<0.05);the level of serum BDNF in treatment group was higher than that in control group,while the level of MBP was lower than that in control group(P<0.05).There were no obvious adverse reactions during the treatment.Conclusion Huoxue Tongmai Decoction soaking can enhance the nerve conduction velocity of patients with diabetic peripheral neuropathy,and improve the clinical symptoms of patients,and its mechanism may be related to the increase of BDNF contents and reduce of the MBP contents.
作者
邓莉娟
鞠上
杨博华
杨光耀
王宁
张素明
任莹莹
王刚
DENG Lijuan;JU Shang;YANG Bohua;YANG Guangyao;WANG Ning;ZHANG Suming;REN Yingying;WANG Gang(The First Clinical Medical College,Beijing University of Chinese Medicine,Beijing100029,China;Department of Peripheral Vascular,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing100700,China;Department of Surgical,Beijing Shijingshan Hospital of Traditional Chinese Medicine,Beijing100043,China)
出处
《中国医药导报》
CAS
2022年第24期86-89,共4页
China Medical Herald
基金
国家重点研发计划项目(2019YFC1709302)
北京中医药大学青年教师项目(2017-JYB-JS-160)。
关键词
糖尿病周围神经病变
中药溻渍
活血通脉方
甲钴胺
脑源性神经营养因子
髓鞘碱性蛋白
Diabetic peripheral neuropathy
Traditional Chinese medicine soaking
Huoxue Tongmai Decoction
Mecobalamin
Brain derived neurotrophic factor
Myelin basic protein
