摘要
铁死亡是一种有别于细胞凋亡的铁依赖性细胞死亡方式。目前发现的铁死亡诱导药物主要有胱氨酸/谷氨酸反向转运体抑制剂、谷胱甘肽过氧化物酶4(GPX4)抑制剂和芬顿(Fenton)反应诱导剂3大类,可通过多种途径或靶点诱导癌细胞铁死亡,对已产生多药耐药的恶性肿瘤细胞亦具有良好杀伤潜力,如通过直接或间接影响GPX4而抑制GPX4蛋白水平和活性、诱导芬顿反应氧化Fe^(2+)或促进脂质过氧化物积聚等机制诱导铁死亡。本文综述铁死亡诱导药物及其抗癌机制,为探索基于铁死亡的癌症治疗策略及抗癌制剂开发提供有益参考。
Unlike apoptosis,ferroptosis is a mode of iron-dependent cell death.The ferroptosisinducing drugs discovered so far can induce ferroptosis in cancer cells through various pathways or targets and have a great potential to inhibit the malignant multidrug-resistant tumors.These ferroptosisinducing drugs are of three categories:cystine/glutamate antiporter inhibitors,glutathione peroxidase 4(GPX4)inhibitors,and Fenton reaction-like inducers.For example,ferroptosis is induced by directly or indirectly affecting GPX4,inhibiting GPX4 protein levels and activities,inducing Fenton reaction to oxidize Fe^(2+) and promoting lipid peroxide accumulation.This article reviews the ferroptosis-inducing drugs and their anticancer mechanisms in hopes of providing helpful information about ferroptosis-based cancer therapy and drug development.
作者
季鹏
王祥龙
葛健文
张雅洁
柳熠
张进香
吴正红
JI Peng;WANG Xiang-long;GE Jian-wen;ZHANG Ya-jie;LIU Yi;ZHANG Jin-xiang;WU Zheng-hong(College of Pharmacy and Chemistry and Chemical Engineering,Taizhou College,Taizhou 225300,China;College of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)
出处
《中国药理学与毒理学杂志》
CAS
北大核心
2022年第6期473-480,共8页
Chinese Journal of Pharmacology and Toxicology
基金
江苏省高等学校基础科学(自然科学)研究项目资助(21KJB350018)
泰州学院博士基金(TZXY2020QDJJ009)
江苏省大学生创新训练计划项目(202212917018Z)
泰州学院2022届优秀毕业设计(论文)培育计划项目(2022YP141)。
