摘要
细菌耐药性问题逐渐成为临床治疗和防控感染性疾病的重大挑战。本文结合美国、欧洲及我国的药敏试验相关标准,对目前临床主要细菌耐药表型的分子机制、检测方法及结果解读进行介绍。了解临床重要细菌耐药表型的分子机制,有助于更好地开展药物敏感性检测,快速、准确地发布临床报告。
Antibiotic resistance has gradually become a major challenge for clinical treatment and prevention and control of infectious diseases.Based on the relevant standards of drug susceptibility test in the United States,Europe and China,this paper introduces the molecular mechanism,detection methods and interpretation of the results of drug resistance phenotypes of major clinical bacteria.Understanding the molecular mechanism of drug resistance phenotype of clinically important bacteria is helpful for better drug sensitivity detection,and rapid and accurate release of clinical reports.
作者
陆旻雅
刘亚丽
张丽
徐英春
LU Min-ya;LIU Ya-li;ZHANG Li;XU Ying-chun(Department of Clinical Laboratory,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases,Beijing 100730,China)
出处
《中国合理用药探索》
2022年第8期12-19,共8页
Chinese Journal of Rational Drug Use
基金
北京市临床重点专科医学检验科卓越项目(ZK201000)
中国医学科学院医学与健康科技创新工程(2021-I2M-1-044)。
关键词
感染性疾病
细菌耐药性
分子机制
药物敏感性试验
临床解读
infectious diseases
antibiotic resistance
molecular mechanisms
drug sensitivity tests
clinical interpretation
