摘要
目的探究自拟地仲骨坚汤治疗骨质疏松症伴腰椎退行性病变(肾虚血瘀证)的临床疗效。方法选取2018年2月至2020年12月本院收治的80例骨质疏松症伴腰椎退行性病变(肾虚血瘀证)患者作为研究对象,根据治疗方法不同分为地仲骨坚汤组和钙尔奇组,每组40例。钙尔奇组给予钙尔奇口服治疗,地仲骨坚汤组在钙尔奇组基础上联合自拟地仲骨坚汤治疗,比较两组治疗3个月后骨代谢、骨密度及炎症因子水平。结果治疗前,两组Ⅰ型胶原羟基末端肽(CTX)、骨钙素(BGP)、骨特异性碱性磷酸酶(B-ALP)及Ⅰ型前胶原N端前肽(PⅠNP)水平比较差异无统计学意义;治疗后,两组CTX、BGP、B-ALP及PⅠNP水平均低于治疗前,且地仲骨坚汤组低于钙尔奇组,差异有统计学意义(P<0.05)。治疗前,两组腰椎L_(2-4)、股骨颈骨密度(BMD)水平比较差异无统计学意义;治疗后,两组腰椎L2~4、股骨颈BMD水平均高于治疗前,且地仲骨坚汤组高于钙尔奇组,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)与胰岛素样生长因子-1(IGF-1)水平比较差异无统计学意义;治疗后,两组IL-6、TNF-α水平均低于治疗前,IGF-1水平均高于治疗前,且地仲骨坚汤组IL-6、TNF-α水平低于钙尔奇组,IGF-1水平高于钙尔奇组,差异有统计学意义(P<0.05)。结论仲骨坚汤治疗肾虚血瘀证骨质疏松症伴腰椎退行性病变疗效显著,可有效改善患者骨代谢水平,提高骨密度,降低炎症因子水平,值得临床推广应用。
Objective To explore the clinical efficacy of self-made Dizhong Gujian decoction in the treatment of osteoporosis with lumbar degenerative disease(kidney deficiency and blood stasis syndrome).Methods 80 patients with osteoporosis with lumbar degenerative disease(kidney deficiency and blood stasis syndrome)who were treated in the hospital between February 2018 and December 2020 were selected as the research subjects,and they were divided into Dizhong Gujian decoction group and caltrate group according to different treatment methods,with 40 cases in each group.The caltrate group was given oral administration of caltrate,and the Dizhong Gujian decoction group was combined with self-made Dizhong Gujian decoction on the basis of the caltrate group,the bone metabolism,bone mineral density and inflammatory factors were compared between the two groups after 3 months of treatment.Results Before treatment,there were no statistical differences in the levels of C-telopeptides typeⅠcollagen(CTX),osteocalcin(BGP),bone-specific alkaline phosphatase(B-ALP)and procollagenⅠN-terminal peptide(PⅠNP)between the two groups;after treatment,the levels of CTX,BGP,B-ALP and PⅠNP in both groups were lower than those before treatment,and the levels in Dizhong Gujian decoction group were lower than those in caltrate group,the differences was statistically significant(P<0.05).There were no statistical differences in the bone mineral density(BMD)of lumbar spine L_(2-4)and femoral neck between the two groups before treatment,after treatment,the BMD of lumbar spine L_(2-4) and femoral neck in the two groups were higher than those before treatment,and the Dizhong Gujian decoction group were higher than those in caltrate group,the differences was statistically significant(P<0.05).Before treatment,there were no statistical differences in the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),insulin-like growth factor(IGF-1)between the two groups;after treatment,the levels of IL-6 and TNF-αin the two groups were lower than thos
作者
徐通
吕国攀
尤日均
张绪森
XU Tong;LYU Guopan;YOU Rijun;ZHANG Xusen(Department of Orthopedics,Shangrao Hospital of Traditional Chinese Medicine,Shangrao,Jiangxi,334000,China)
出处
《当代医学》
2022年第23期88-91,共4页
Contemporary Medicine
关键词
自拟地仲骨坚汤
骨质疏松症
腰椎退行性病变
肾虚血瘀证
Self-made Dizhong Gujian decoction
Osteoporosis
Lumbar degenerative disease
Kidney deficiency and blood stasis syndrome
