摘要
目的 观察通脉温阳灸治疗乳腺癌癌因性疲乏的临床疗效。方法 将60例乳腺癌癌因性疲乏患者采用随机数字表法分为对照组和治疗组,各30例。2组均予含紫杉醇类药物的标准乳腺癌化疗方案治疗2个化疗周期,在化疗期间,对照组通过心理、饮食、运动、睡眠调摄改善患者疲乏;治疗组在对照组常规方法的基础上采用通脉温阳灸,从每个化疗周期的第1天开始治疗,连续灸治1周。比较2组治疗前后的Piper疲乏量表(PFS)评分、卡氏(KPS)评分及血清5-羟色胺(5-HT)水平。结果 治疗后2组PFS感觉、情绪、认知3个维度评分及总评分明显降低,KPS评分明显升高,此外,治疗组PFS行为维度评分亦明显降低,与同组治疗前比较差异均有统计学意义(P<0.05),且治疗组各项评分改善更明显,与对照组治疗后比较差异均有统计学意义(P<0.05);治疗后2组血清5-HT水平明显降低,与同组治疗前比较差异均有统计学意义(P<0.05),且治疗组降低更明显,与对照组治疗后比较差异有统计学意义(P<0.05)。结论 通脉温阳灸可明显改善乳腺癌癌因性疲乏患者的疲乏程度,提高患者的生存质量,降低血清5-HT水平,疗效确切。
Objective To observe the clinical efficacy of dredging vessels and warming yang moxibustion in the treatment of breast cancer⁃related fatigue.Methods Sixty cases of breast cancer⁃related fatigue were divided into control group and treatment group according to random number table method,with 30 cases in each group.Both groups were treated with standard chemotherapy regimen for breast cancer containing paclitaxel for 2 chemotherapy cycles.During chemotherapy,the control group improved the fatigue of patients through psychology,diet,exercise and sleep adjustment;The treatment group adopted dredging vessels and warming yang moxibustion on the basis of the routine method of the control group,the treatment began on the first day of each chemotherapy cycle and was continuously treated with moxibustion for 1 week.The Piper Fatigue Scale(PFS)score,the Karnofsky performance scale(KPS)score and serum level 5⁃hydroxytryptamine(5⁃HT)were compared between the 2 groups before and af⁃ter treatment.Results After treatment,the scores in 3 dimensions of PFS including sensory,affect and cognition and the overall scores in the 2 groups decreased significantly,whereas the KPS score increased significantly.In ad⁃dition,the score of behavior dimension in PFS in the treatment group also decreased significantly,which was statisti⁃cally significant compared with that in the same group before treatment(P<0.05),moreover,the various items scores in the treatment group improved more significantly,which were statistically significant compared with those in the control group after treatment(P<0.05).The level of serum 5-HT in the 2 groups decreased significantly after treat⁃ment,which was statistically significant compared with that in the same group before treatment(P<0.05),moreover,the decrease in the treatment group was more significant,which was statistically significant compared with that in the control group after treatment(P<0.05).Conclusion Dredging vessels and warming yang moxibustion can markedly improve the fatigue degr
作者
侯小妹
吴勇
马丽
李恬
曾永蕾
HOU Xiaomei;WU Yong;MA Li;LI Tian;ZENG Yonglei(School of Postgraduate,Anhui University of Chinese Medicine,Hefei,Anhui,230038,China;Department of Oncology,the Second Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,Anhui,230038,China;Department of Oncology,Mingguang Hospital of TCM,Mingguang,Anhui,239400,China)
出处
《甘肃中医药大学学报》
2022年第3期74-78,共5页
Journal of Gansu University of Chinese Medicine
基金
安徽省中医药传承创新项目(2020ccyb05)
安徽省自然科学基金面上项目(1608085MH233)
安徽省十三五医疗卫生重点专科项目(皖卫教科[2017]30号)。
关键词
癌因性疲乏
乳腺癌
通脉温阳灸
Piper疲乏量表评分
卡氏评分
5-羟色胺
临床观察
cancer⁃related fatigue
breast cancer
dredging vessels and warming yang moxibustion
Piper Fa⁃tigue Scale(PFS)score
Karnofsky performance scale(KPS)score
5⁃hydroxytryptamine(5⁃HT)
clinical observation
