摘要
目的:探讨载脂蛋白B/载脂蛋白A1(ApoB/A1)比值对子痫前期(PE)患者妊娠结局的预测价值。方法:选取2020年1月至2021年1月郑州大学第二附属医院妇产科收治的112例PE孕妇,根据病情分为轻度PE组(52例)和重度PE组(60例),另选取同期健康孕产妇56例为对照组。根据妊娠结局分为结局良好组(n=62)与结局不良组(n=50)。对比分析3组孕产妇的ApoB、ApoA1及ApoB/A1比值。ROC曲线评估ApoB/A1对PE的诊断价值,logistic回归及ROC曲线分析ApoB/A1对PE妊娠结局的预测价值。结果:与对照组比,轻度及重度PE组的ApoB、ApoB/A1均显著升高(P<0.05),重度PE组的ApoB、ApoB/A1高于轻度PE组(P<0.05),ApoA1水平低于轻度PE组(P<0.05)。ApoA1、ApoB、ApoB/A1诊断PE的曲线下面积(AUC)分别为0.710、0.860和0.882。与妊娠结局良好组相比,妊娠结局不良组的ApoB、ApoB/A1均显著升高,ApoA1降低(P<0.05)。ApoB、ApoB/A1是PE孕妇不良妊娠结局的独立危险因素[OR(95%CI)=2.839(1.096~7.356),P=0.032;OR(95%CI)=3.451(1.363~8.737),P=0.009],其预测妊娠结局的AUC分别为0.750、0.787。结论:ApoB/A1与PE具有一定相关性,对PE孕妇的妊娠结局可能具有预测价值。
Objective:To investigate the predictive value of apolipoprotein B/apolipoprotein A1(ApoB/A1)ratio in pregnancy outcome of preeclampsia(PE).Methods:A total of 112 cases of PE pregnant women admitted to the department of Obstetrics and Gynecology,the Second Affiliated Hospital of Zhengzhou University from January 2020 to January 2021 were selected as the research objects,and were divided into mild PE(n=52)and severe PE group(n=60)according to their conditions,and 56 healthy pregnant women were selected as the control group.According to the pregnancy outcome,the PE pregnant women were divided into the good outcome group(n=62)and poor outcome group(n=50).ApoB,ApoA1 and ApoB/A1 ratio of pregnant women in different groups were compared and analyzed.The diagnostic value of ApoB/A1 for PE was evaluated by ROC curve,and the predictive value of ApoB/A1 for PE pregnancy outcome was analyzed by logistic regression and ROC curve.Results:Compared with the control group,the ApoB and ApoB/A1 in mild and severe PE groups were significantly increased(P<0.05),and the ApoB and ApoB/A1 in severe PE group were higher than mild PE group(P<0.05),and the ApoA1 was lower than mild PE group(P<0.05).The area under curve(AUC)of ApoA1,ApoB and ApoB/A1 were 0.710,0.860 and 0.882,respectively.Compared with good outcome group,ApoB and ApoB/A1 in poor outcome group were significantly increased,while ApoA-1 was decreased(P<0.05).ApoB and ApoB/A1 were independent risk factors for adverse pregnancy outcomes in PE women[OR(95%CI)=2.839(1.096~7.356),P=0.032;OR(95%CI)=3.451(1.363~8.737),P=0.009],and the AUC for predicting pregnancy outcome were 0.750 and 0.787,respectively.Conclusion:ApoB/A1 has certain correlation with PE,which has certain predictive value for the pregnancy outcome of PE pregnant women.
作者
乔小改
蔡大军
张庆
Qiao Xiaogai;Cai Dajun;Zhang Qing(Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)
出处
《现代妇产科进展》
CSCD
北大核心
2022年第8期597-600,604,共5页
Progress in Obstetrics and Gynecology
基金
河南省医学科技攻关计划项目(No:201702091)。
