摘要
This report briefly described the establishment and implementation of national surveillance for human prion disease(PrD)in China.Reported cases came from Chinese surveillance network for PrD.Immunohistochemistry,Western blot,enzyme-linked immunosorbent assay(ELISA),Polymerase Chain Reaction(PCR),and real-time quaking-induced conversion(RT-QuIC)tests were used for the samples of brain,cerebrospinal fluid(CSF),and blood.Diagnosis standard for the PrDs is based on the National Commission of Health(WS/T 562-2017).The study summarized major epidemiological,clinical and laboratory features of more than 2,100 diagnosed different types of Chinese PrD cases.Sporadic Creutzfeldt-Jacob disease(sCJD)is the predominant type of PrD(88.7%).19 different genotypes of genetic PrDs(gPrDs)were identified,accounting for about 11.3%of all PrDs,revealing ethno-relationships.No iatrogenic CJD(iCJD)and variant CJD(vCJD)was identified.The characteristics of different types of sCJD in China showed similar features as those reported globally,but gPrDs showed an obvious ethnorelationship.
基金
Supported by National Key R&D Program of China(2020YFE0205700)
SKLID Development Grant(2021SKLID101,2021SKLID503,2021SKLID504)
National Natural Science Foundation of China(81772197,81630062,81401670).
