摘要
目的 研究血栓通注射液联合甲钴胺片治疗脑梗死的效果及对泛素羧基末端水解酶-L1(UCH-L1)、血清衰老关键蛋白抗原-5(Fibulin-5)水平的影响。方法 回顾性分析2019.2-2020.11我院收治脑梗死患者112例,根据治疗方法不同分为对照组和观察组各56例。入院后对照组给予脑梗死常规治疗和静脉滴注血栓通注射液,观察组在对照组的基础上加用甲钴胺片口服治疗。观察两组患者治疗后的临床疗效和两组患者在治疗前后UCH-L1、Fibulin-5水平。结果 观察组临床总有效率高于对照组(78.6%vs 60.7%,P<0.05);两组患者治疗后UCH-L1、Fibulin-5值明显降低,且对照组UCH-L1、Fibulin-5值高于观察组(P<0.05)。结论 血栓通注射液联合甲钴胺片治疗脑梗死疗效显著,且能有效降低UCH-L1、Fibulin-5水平。
Objective To study the effect of Xueshuantong injection combined with mecobalamin tablets in the treatment of cerebral infarction and on the levels of ubiquitin carboxy-terminal hydrolase-L1(UCH-L1)and Fibulin-5.Methods A retrospective analysis was conducted in 112 patients with cerebral infarction in our hospital from February 2019 to November 2020,and they were divided into control group and observation group with 56 cases in each group according to different treatment methods.After admission,the control group was given conventional cerebral infarction plus intravenous drip of Xueshuantonginjection,and the observation group was given oral mecobalamin tablets on the basis of the control group.The clinical efficacy after treatment and the levels of UCH-L1 and Fibulin-5 in the two groups before and after treatment were observed.Results The total clinical effective rate of the observation group was higher than that of the control group(78.6%vs 60.7%,P<0.05).After treatment,the UCH-L1 and Fibulin-5 values of the two groups were significantly reduced,and the values of the control group were higher than the observation group(P<0.05).Conclusion Xueshuantonginjection combined with mecobalamin tablets has a significant effect in the treatment of cerebral infarction,and can effectively reduce the levels of UCH-L1 and Fibulin-5.
作者
周洪胜
韩金权
Zhou Hongsheng;Han Jinquan(Xinyang Medical District,990 Hospital of Joint Logistics Support Force,464000,Xinyang,Henan)
出处
《辽宁医学杂志》
2022年第4期32-34,共3页
Medical Journal of Liaoning
