摘要
目的:探讨血清趋化素(CHEM)、网膜素-1(Omentin-1)与银屑病患者炎症细胞因子和代谢综合征(MS)的关系。方法:选取2020年1月~2021年1月我院收治的137例银屑病患者,其中40例轻度、58例中度、39例重度,根据是否合并MS分为MS组(n=59)、非MS组(n=78)。收集患者一般资料和实验室指标,采用酶联免疫吸附测定法(ELISA)检测血清白细胞介素(IL)-17、IL-22、IL-23、CHEM、Omentin-1水平。Pearson/Spearman系数分析银屑病患者血清CHEM、Omentin-1水平与炎症因子水平和病情严重程度的相关性,多因素Logistic回归分析银屑病合并MS影响因素。结果:与轻度组比较,中度组、重度组血清CHEM、IL-17、IL-22、IL-23水平升高,Omentin-1水平降低(P<0.05);与轻、中度组比较,重度组血清CHEM、IL-17、IL-22、IL-23水平升高,Omentin-1水平降低(P<0.05)。银屑病患者血清CHEM水平与IL-17、IL-22、IL-23水平和病情严重程度呈正相关(r/rs=0.370、0.471、0.500、0.624,P均<0.05);Omentin-1水平与IL-17、IL-22、IL-23水平和病情严重程度呈负相关(r/rs=-0.392、-0.423、-0.475、-0.533,P均<0.05)。与非MS组比较,MS组血清IL-17、IL-22、IL-23、CHEM水平升高,Omentin-1水平降低(P<0.05)。CHEM(OR=1.098,95%CI:1.027~1.174,P=0.006)、Omentin-1(OR=0.775,95%CI:0.674~0.891,P=0.001)为银屑病合并MS的影响因素。结论:血清CHEM、Omentin-1水平变化与银屑病患者病情严重程度和炎症反应相关,为银屑病合并MS影响因素,可能作为银屑病合并MS早期监测指标。
Objective:To investigate the relationship between serum chemerin(CHEM)and Omentin-1(Omentin-1)and inflammatory cytokines and metabolic syndrome(MS)in patients with psoriasis.Methods:A total of 137 patients with psoriasis who were admitted to the our hospital from January 2020 to January 2021 were selected,of whom 40 cases were mild,58 cases were moderate and 39 cases were severe,they were divided into MS group(n=59)and non-MS group(n=78)according to whether they were combined with MS.General data and laboratory indicators of patients were collected,and serum interleukin(IL)-17,IL-22,IL-23,CHEM and Omentin-1 levels were measured by enzyme linked immunosorbent assay(ELISA).Pearson/Spearman coefficients were used to analyze the correlation between serum CHEM and Omentin-1 levels and inflammatory factor levels and severity of disease in patients with psoriasis,and multivariate Logistic regression was used to analyze the influencing factors for psoriasis combined with MS.Results:Compared with the mild group,serum CHEM,IL-17,IL-22 and IL-23 levels increased,and Omentin-1 levels decreased in the moderate group and severe group(P<0.05).Compared with the mild and moderate group,serum CHEM,IL-17,IL-22 and IL-23 levels increased,and Omentin-1 levels decreased in the severe group(P<0.05).Serum CHEM levels in patients with psoriasis were positively correlated with IL-17,IL-22,IL-23 levels and severity of disease(r/rs=0.370,0.471,0.500,0.624,all P<0.05).Omentin-1 levels were negatively correlated with IL-17,IL-22,IL-23 levels and severity of disease(r/rs=-0.392,-0.423,-0.475,-0.533,all P<0.05).Compared to the non-MS group,the MS group serum IL-17,IL-22,IL-23 and CHEM levels were increased,and Omentin-1 level was decreased(P<0.05).CHEM(OR=1.098,95%CI:1.027~1.174,P=0.006),and Omentin-1(OR=0.775,95%CI:0.674~0.891,P=0.001)were independent influencing factors for psoriasis combined with MS.Conclusion:The changes of serum CHEM and Omentin-1 levels are correlated with the severity of disease of psoriasis and inflammatory response,whi
作者
丁香玉
李承新
王睿
朱文巍
解方
杨怡
DING Xiang-yu;LI Cheng-xin;WANG Rui;ZHU Wen-wei;XIE Fang;YANG Yi(Department of Dermatology,The First Medical Center of PLA General Hospital,Beijing,100853,China)
出处
《现代生物医学进展》
CAS
2022年第12期2270-2274,2317,共6页
Progress in Modern Biomedicine
基金
北京市科技计划项目(Z181100001718038)。
