摘要
传染性病原体的即时检测(Point-of-care testing,POCT)对于及时有效控制传染病尤为关键。相比于传统检测方法,基于电化学免疫传感器的传染性病原体检测具有快速、灵敏、准确、易于小型化和集成化等优势,尤其适用于传染病的POCT。新兴的纳米材料因其独特的理化性质可用于修饰传感器界面或作为生物分子的固载基质以及信号标记物等,有助于构建出高选择性和高灵敏度的电化学免疫传感器。本文着重阐述了不同结构纳米材料修饰的电化学免疫传感器在传染性病原体POCT检测中的应用,进一步介绍了基于纳米材料的电化学免疫传感器与不同检测技术联用在传染性病原体POCT中的应用,并对其发展前景作出了展望。
The application of POCT for infectious pathogen is particularly critical for controlling infectious diseases in a timely and effective manner.Compared to traditional methods for pathogen detection,the detection of infectious pathogen based on electrochemical immunosensors is featured by rapid detection speed,high accuracy and sensitivity,and integration accessibility to miniaturization,which is especially suitable for application in POCT for infectious pathogen.Due to their unique physical and chemical properties,emerging nanomaterials can be used to modify sensing interface,immobilize biomolecules and amplify detection signals,which contribute to the construction of electrochemical immunosensors with high selectivity and sensitivity.In this paper,we focused on the application of different structural nanomaterial-modified electrochemical immunosensors in POCT for infectious pathogen.Moreover,the application of different structural nanomaterial-modified electrochemical immunosensors combined with different detection techniques in POCT for infectious pathogen was further introduced,and then the development trend of electrochemical immunosensors in POCT for infectious pathogen was also discussed.
作者
王思远
张悦
张国军
沈昕
Wang Siyuan;Zhang Yue;Zhang Guojun;Shen Xin(Department of Laboratory Medicine,Hubei University of Chinese Medicine,Wuhan,430065)
出处
《化学通报》
CAS
CSCD
北大核心
2022年第8期918-926,共9页
Chemistry
基金
国家自然科学基金项目(21974035,82174344)资助。
关键词
纳米材料
电化学免疫传感器
POCT
传染性病原体
Nanomaterials
Electrochemical immunosensor
Point-of-care testing
Infectious pathogen
