摘要
目的探讨血清可溶性胎盘血管内皮生长因子受体-1(sFlt-1)、胎盘生长因子(PIGF)和补体系统激活因子水平预测孕中期(20~26周)孕妇子痫前期(PE)发病的价值。方法选取2018年6月至2020年6月嘉兴市妇幼保健院产科就诊的至少有1项PE危险因素的孕中期孕妇300例,将发展为PE的46例设为发病组,剩下254例设为未发病组。比较两组孕妇sFlt-1、PIGF、sFlt-1/PIGF、补体3(C3)和B因子水平,并采用ROC曲线评估各项血清指标预测PE的效能。结果发病组孕妇血清s Flt-1、sFlt-1/PIGF、C3和B因子水平均高于未发病组,PIGF水平低于未发病组,差异均有统计学意义(均P<0.01)。ROC曲线显示,sFlt-1、PIGF、sFlt-1/PIGF、C3和B因子预测PE的AUC分别为0.662、0.771、0.789、0.643和0.691,在对PE的预测中sFlt-1/PIGF效能最佳,其截断值为3.4,灵敏度和特异度分别为0.859、0.771。结论PE孕妇机体内sFlt-1、PIGF、sFlt-1/PIGF、C3和B预测PE因子存在异常,对PE的预测具有一定价值。
Objective To investigate the value of serum soluble fms-like tyrosine kinase-1(sFlt-1),placental growth factor(PIGF)and complement system activators in predicting preeclampsia(PE)in second trimester(20-26 weeks)pregnant women.Methods Three hundred pregnant women in the second trimester with at least one PE risk factor who visited the Department of Obstetrics of Jiaxing Maternal and Child Health Hospital from June 2018 to June 2020 were enrolled.Among them,PE developed in 46 cases(PE group),and the remaining 254 cases were set as non-PE group.The levels of sFlt-1,PIGF,sFlt-1/PIGF,C3 and factor B were compared between the two groups,and the ROC curve was used to evaluate the efficacy of these indicators in predicting PE in second trimester pregnant women.Results Serum levels of sFlt-1,sFlt-1/PIGF,C3 and factor B in the PE group were higher than those in the non-PE group,and PIGF level was lower than that in the non-PE group(all P<0.01).The ROC curve showed that AUC of sFlt-1,PIGF,sFlt-1/PIGF,C3 and factor B were 0.662,0.771,0.789,0.643 and 0.691,respectively.In the prediction of PE,sFlt-1/PIGF had the best performance,with a cut-off value of 3.4,and a sensitivity and specificity of 0.859 and 0.771,respectively.Conclusion The abnormality of sFlt-1,PIGF,sFlt-1/PIGF,C3 and factor B in PE pregnant women has certain value in the prediction of PE.
作者
曹云飞
马蔷
孙丹丹
黄萍华
CAO Yunfei;MA Qiang;SUN Dandan;HUANG Pinghua(Department of Obstetrics,Jiaxing Maternal and Child Health Hospital,Jiaxing 314000,China;不详)
出处
《浙江医学》
CAS
2022年第15期1624-1626,1631,共4页
Zhejiang Medical Journal
基金
浙江省基础公益性研究计划项目(LGF20H040011)
嘉兴市科技计划(公益性研究计划)项目(2018AY32020)。
