摘要
目的探讨闽南经方四神汤加减治疗在小儿哮喘缓解期的应用效果。方法选取2020年1月至2021年6月在厦门大学附属东南医院儿科治疗的106例小儿哮喘缓解期患儿作为研究对象,采用随机数字表法分为对照组和观察组,每组各53例,对照组使用常规西医治疗,观察组在此基础上使用闽南经方四神汤加减治疗,比较两组的疗效及安全性。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组呼出气一氧化氮(FeNO)、急诊次数以及哮喘发作次数均低于对照组,差异有统计学意义(P<0.05);观察组治疗后的中医证候积分低于对照组,差异有统计学意义(P<0.05);观察组治疗后的肺功能指标高于对照组,差异有统计学意义(P<0.05);观察组治疗后CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组,差异有统计学意义(P<0.05);两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论哮喘缓解期患儿选择闽南经方四神汤加减治疗可获得良好效果,可显著改善临床症状,并且提升肺功能,调整机体免疫功能,且安全性高。
Objective To discuss the application effects of modified Minnan Jingfang Sishen Decoction in remission stage of asthma children.Methods A total of 106 remission stage of asthma children from January 2020 to June 2021 in Department of Pediatrics,the Affiliated Dongnan Hospital of Xiamen University were selected as research subjects.They were divided into the control group and the observation group by random number table method,with 53 cases in each group.The control group took western medicine,and the observation group took western medicine and modified Minnan Jingfang Sishen Decoction.Treatment effects and safety were probed.Results The total effective rate in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).Exhaled nitric oxide(FeNO),emergency frequency and asthma attack frequency in the observation group were lower than those in the control group,with statistically significant difference(P<0.05).Traditianal Chinese medicine symptom scores in the observation group were lower than those in the control group,with statistically significant difference(P<0.05).After treatment,lung function indicators in the observation group were higher than those in the control group,with statistically significant difference(P<0.05).CD4^(+)and CD4^(+)/CD8^(+)levels in the observation group were higher than those in the control group,and CD8^(+)level was lower than that in the control group,with statistically significant difference(P<0.05).The total incidences of adverse reactions between two groups showed no statistically significant difference(P>0.05).Conclusion The modified Minnan Jingfang Sishen Decoction can reduce the clinical symptoms,and improve the lung function,immune function and treatment safety for remission stage of asthma children.
作者
陈少全
滕飞
林茂增
CHEN Shaoquan;TENG Fei;LIN Maozeng(Department of Pediatrics,No.909 Hospital of the Joint Logistic Support Force,the Affiliated Dongnan Hospital of Xiamen University,Fujian Province,Zhangzhou363000,China)
出处
《中国当代医药》
CAS
2022年第23期91-94,98,共5页
China Modern Medicine
关键词
小儿哮喘缓解期
闽南经方四神汤加减
肺功能
免疫功能
不良反应
Remission stage of asthma
Modified Minnan Jingfang Sishen Decoction
Lung function
Immune function
Adverse reactions
