摘要
目的分析肺炎支原体肺炎患儿血清趋化因子配体17(CCL17)水平与疾病严重程度的相关性。方法选取2019年10月至2021年10月该院收治的114例肺炎支原体肺炎患儿作为研究组,根据重症肺炎支原体肺炎诊断标准分为轻症组(65例)、重症组(49例)。另选取同期68例肺炎衣原体肺炎患儿作为疾病对照组,70例体检健康儿童作为对照组。采用酶联免疫吸附试验(ELISA)检测血清CCL17水平,比较研究组与对照组及不同严重程度患儿血清CCL17水平差异。采用Pearson相关分析血清CCL17水平与临床肺部感染评分(CPIS)的相关性,采用受试者工作特征(ROC)曲线分析血清CCL17水平对重症肺炎支原体肺炎的评估价值,采用多因素Logistic回归分析影响重症肺炎支原体肺炎发生的相关因素。结果研究组血清CCL17、C反应蛋白(CRP)、白细胞计数(WBC)及CPIS均明显高于对照组(P<0.05),且研究组血清CCL17水平明显高于疾病对照组(P<0.05),重症组血清CCL17、CRP、WBC及CPIS均明显高于轻症组(P<0.05)。Pearson相关分析结果显示,肺炎支原体肺炎患儿血清CCL17水平与CPIS、CRP、WBC均呈正相关(r=0.652、0.502、0.414,均P<0.05)。ROC曲线分析结果显示,CCL17诊断肺炎支原体肺炎曲线下面积(AUC)为0.785,高于CPIS(AUC=0.682)和CRP(AUC=0.633)。多因素Logistic回归分析结果显示,血清CCL17、CRP、CPIS均是重症肺炎支原体肺炎发生的独立影响因素(P<0.05)。结论血清CCL17水平在肺炎支原体肺炎患儿中明显升高,且随着疾病加重而逐渐升高,其可作为评估肺炎支原体肺炎病情进展的有效指标。
Objective To investigate the correlation of serum chemokine ligand 17(CCL17)level and disease severity in children with Mycoplasma pneumoniae pneumonia.Methods A total of 114 children with Mycoplasma pneumoniae pneumonia admitted to our hospital from October 2019 to October 2021 were selected as the research group,and were divided into mild group(65 cases)and severe group(49 cases)according to the diagnostic criteria of severe Mycoplasma pneumoniae pneumonia.In addition,68 children with Chlamydia pneumoniae pneumonia were selected as the disease control group and 70 healthy children were selected as the control group.The serum level of CCL17 was determined by enzyme-linked immunosorbent assay(ELISA).The serum levels of CCL17 between the study group and the control group as well as children with different severity were compared.The correlation between serum CCL17 and clinical pulmonary infection score(CPIS)was analyzed by Pearson correlation analysis,and the evaluation value of serum CCL17 for severe Mycoplasma pneumoniae pneumonia was analyzed by receiver operating characteristic(ROC)curve.Meanwhile,the related factors affecting the occurrence of severe Mycoplasma pneumoniae pneumonia were analyzed by multivariate Logistic regression model.Results Serum CCL17,CRP,WBC and CPIS in the study group were significantly higher than those in the control group(P<0.05).The serum CCL17 level in the study group was significantly higher than that in the disease control group(P<0.05).The serum CCL17,CRP,WBC and CPIS in the severe group were significantly higher than those in the mild group(P<0.05).Pearson correlation analysis showed that serum CCL17 level was positively correlated with CPIS,CRP,WBC in children with Mycoplasma pneumoniae pneumonia(r=0.652,0.502,0.414,all P<0.05).ROC curve analysis showed that the area under curve(AUC)of CCL17(AUC=0.785)was higher than those of CPIS(AUC=0.682)and CRP(AUC=0.633).Multivariate Logistic regression analysis showed that serum CCL17,CRP and CPIS were all independent factors affecting t
作者
孙晓丽
颜鲁霞
吴娥玲
SUN Xiaoli;YAN Luxia;WU Eling(Department of Pediatrics,Xining Second People′s Hospital,Xining,Qinghai 810003,China;Department of Clinical Laboratory,Xining Second People′s Hospital,Xining,Qinghai 810003,China)
出处
《国际检验医学杂志》
CAS
2022年第16期2004-2007,2011,共5页
International Journal of Laboratory Medicine
关键词
肺炎支原体肺炎
趋化因子配体17
临床肺部感染评分
儿童
Mycoplasma pneumoniae pneumonia
chemokine ligand 17
clinical pulmonary infection score
children
