摘要
目的分析1990-2019年全球斑秃疾病负担的变化趋势,为全球各个国家的斑秃防治提供理论依据。方法根据2019年全球疾病负担(GBD 2019)研究,采用伤残调整寿命年(DALY)、标化DALY率以及估计年百分比变化(EAPC)等指标分析1990-2019年全球斑秃疾病负担的变化趋势。结果2019年,全球斑秃共导致600570.37(95%UI:378239.38~891060.98)人年DALY,相比1990年增长了49.51%,但标化DALY率下降了2.93%。在各年龄组中,女性的DALY及DALY率均高于同年龄段的男性。从全球来看,1990-2019年斑秃标化DALY率增长最快的是低社会人口指数地区(EAPC=0.037,95%UI:0.033~0.040),下降最快的是高社会人口指数地区(EAPC=-0.158,95%UI:-0.192~-0.124);在GBD地区中,增长最快的是西撒哈拉以南非洲地区(EAPC=0.065,95%UI:0.056~0.075),下降最快的是撒哈拉以南非洲南部地区(EAPC=-0.031,95%UI:-0.035~-0.028);在国家层面,增长最快的是科威特(EAPC=0.147,95%UI:0.105~0.188),下降最快的是美国(EPAC为-0.291,95%UI:-0.389~-0.193)。此外,2019年人类发展指数与斑秃的标化DALY率呈正相关(r=0.51,P<0.05),而与标化DALY率的EAPC呈负相关(r=-0.29,P<0.05)。结论1990-2019年全球斑秃的疾病负担虽有所改善但总体上仍处于较高水平。25~39岁年龄段人群作为斑秃负担最重的群体,尤其是女性,应重点关注。
Objective To analyze the changing trend of global alopecia areata disease burden from 1990 to 2019,to provide a theoretical basis for the prevention and control of alopecia areata in various countries around the world.Methods Data from global alopecia areata burden of disease was collected and analyzed to assess burden trends from 1990 to 2019 used indicators as disability-adjusted life years(DALY),age-standardized DALY rate,and estimated annual percentage changes(EAPC)based on the GBD 2019.Results In 2019,global alopecia areata resulted in 600570.37(95%UI:378239.38,891060.98)person-year DALY losses.Compared with 1990,it increased by 49.51%,whereas the age-standardized DALY rate decreased 2.93%.The DALY and DALY rates of women were higher than those of men at the same age group.Globally,the age-standardized DALY rates increased most rapidly in the low SDI areas(EAPC=0.037,95%UI:0.033,0.040),and obvious decrease in high SDI areas(EAPC=-0.031,95%UI:-0.035--0.028);at GBD region levels,the age-standardized DALY rate of alopecia areata increased most rapidly in Western Sub-Saharan Africa(EAPC=0.065,95%UI:0.056,0.075)and fastest decline was observed in Southern Sub-Saharan Africa(EAPC=-0.031,95%UI:-0.035,-0.028);at national levels,the age-standardized DALY rates increased most rapidly in Kuwait(EAPC=0.147,95%UI:0.105,0.188),and obvious decrease in America(EPAC=-0.291,95%UI:-0.389,-0.193).In addition,the human development index in 2019 was positively correlated with the standardized DALY rate(r=0.51,P<0.05),while it was negatively correlated with the EAPC of the age-standardized DALY rate(r=-0.29,P<0.05).Conclusion Despite the burden of global alopecia areata from 1990 to 2019 improved,it remains at a high level.The population aged 25-39 is the group with the heaviest burden of alopecia areata.Women should be given more attention.
作者
陈东宇
杨晓雨
樊文龙
王红心
刘兴华
林泳煌
何玉清
CHEN Dongyu;YANG Xiaoyu;FAN Wenlong;WANG Hongxin;LIU Xinghua;LIN Yonghuang;HE Yuqing(Department of Epidemiology and Medical Statistics,Institute of Medical Systems Biology,Guangdong Medical University,Dongguan 523808,China;Department of Dermatology,Liaobu Hospital of Dongguan,Dongguan 523400,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2022年第7期763-768,共6页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金(81773312)
广东省自然科学基金(2015A030313517)
广东省“扬帆计划引进紧缺拔尖”人才项目(201433005)。
