摘要
目的观察基于微信平台的延续护理对居家注射肿瘤坏死因子α(TNF-α)拮抗剂的银屑病患者用药安全性及依从性等的影响,为患者居家安全有效使用生物制剂提供指导。方法选择2020年1—12月在大连市皮肤病医院出院居家注射TNF-α拮抗剂的86例中重度银屑病患者作为研究对象,按照随机数字表法将其分为对照组和观察组,每组43例。对照组接受常规的注射指导及电话随访,观察组在对照组的基础上给予基于微信平台的延续护理。于出院3个月后采用8条目Morisky服药依从性量表(MMAS-8)评估2组患者的用药依从性,出院前和出院3个月后采用银屑病皮损面积及严重程度指数(PASI)评估2组患者的疗效,出院1个月后统计2组患者不良反应。结果出院3个月后,观察组MMAS-8评分为(7.26±1.28)分,高于对照组的(5.13±1.42)分,差异有统计学意义(t=7.31,P<0.01)。2组患者出院前PASI评分比较差异无统计学意义(P>0.05),出院3个月后,观察组PASI评分为(2.69±1.45)分,低于对照组的(5.74±1.32)分,差异有统计学意义(t=10.12,P<0.01)。观察组总有效率为97.67%(42/43),高于对照组的93.02%(40/43),差异有统计学意义(χ^(2)=2.35,P<0.05)。观察组患者的不良反应发生率为6.98%(3/43),低于对照组的18.60%(8/43),差异有统计学意义(χ^(2)=6.05,P<0.05)。结论基于微信平台的延续护理能够有效降低居家注射TNF-α拮抗剂的银屑病患者的不良反应,提升其用药依从性,从而提高居家注射的安全性、有效性。
Objective To observe the effect of continuous nursing care based on Wechat platform on the drug safety and compliance in patients with psoriasis at home injection of tumor necrosis factorα(TNF-α)antagonists,so as to provide guidance for patients to use biological agents safely and effectively at home.Methods A total of 86 patients with moderate to severe psoriasis who were discharged from Dalian Dermatology Hospital from January to December 2020,injected with TNF-αantagonist at home were selected as the study subjects.They were divided into control group and observation group by random digits table method with 43 cases in each group.The control group received routine injection guidance and telephone follow-up;the observation group used continuous nursing care based on Wechat platform on the basis of the control group.Three months after discharge,the medication compliance of the two groups was evaluated by Morisky Medication Adherence Scale-8(MMAS-8).Before discharge and three months after discharge,the efficacy of the two groups was evaluated by psoriasis area and severity index(PASI).One month after discharge,the adverse reactions of the two groups were counted.Results The MMAS-8 score was 7.26±1.28 in the observation group and 5.13±1.42 in the control group three months after discharge,the difference was statistically significant(t=7.31,P<0.01).There was no significant difference in PASI score between the two groups before discharge(P>0.05).Three months after discharge,the PASI score was 2.69±1.45 in the observation group and 5.74±1.32 in the control group,the difference was statistically significant(t=10.12,P<0.01).The total effective rate was 97.67%(42/43)in the observation group and 93.02%(40/43)in the control group,the difference was statistically significant(χ^(2)=2.35,P<0.05).The incidence of adverse reactions was 6.98%(3/43)in the observation group and 18.60%(8/43)in the control group,the difference was statistically significant(χ^(2)=6.05,P<0.05).Conclusions In the treatment of patients with ps
作者
林杰
冯莉
薛琳
Lin Jie;Feng Li;Xue Lin(Second Dermatology Ward,Dalian Dermatology Hospital,Dalian 116021,China)
出处
《中国实用护理杂志》
2022年第20期1553-1558,共6页
Chinese Journal of Practical Nursing
