摘要
目的:探讨肠道菌群对轮状病毒疫苗免疫效果的影响。方法:回顾性分析2018年6月至2019年6月于该院接种五价轮状病毒疫苗的560名婴幼儿的临床资料,统计儿童接种前各种肠道菌群数量及肠道菌群失调发生率,并根据菌群失调情况将其分为正常组(n=458)与失调组(n=102),比较两组中和抗体阳性率、免疫球蛋白(IgG、IgA)水平、随访3年内轮状病毒感染率及重度急性胃肠炎(AGE)发生率。结果:560名婴幼儿中,菌群失调发生率为18.21%(102/560);正常组双歧杆菌、乳酸杆菌数量均大于失调组,金黄色葡萄球菌、沙门菌数量均小于失调组,差异有统计学意义(P<0.05);两组大肠杆菌数量比较,差异无统计学意义(P>0.05);正常组轮状病毒G1、G2、G3、G4、G9型抗原的抗体阳性率及IgG、IgA水平均显著高于失调组,差异有统计学意义(P<0.05);正常组轮状病毒感染率为1.31%(6/458)、重度AGE发生率为0.44%(2/458),显著低于失调组的15.69%(16/102)、8.82%(9/102),差异均有统计学意义(P<0.05)。结论:肠道菌群失调会影响儿童接种轮状病毒疫苗后的免疫效果,肠道菌群正常有助于提高疫苗有效率,预防轮状病毒感染和重度AGE的发生。
Objective:To explore influence of intestinal flora on immune effects of rotavirus vaccine.Methods:The clinical data of 560 infants and young children who received pentavalent rotavirus vaccine in our hospital from June 2018 to June 2019 were retrospectively analyzed.The number of intestinal flora and the incidence of intestinal flora imbalance in these children before vaccination were statistically analyzed.They were divided into normal group(n=458)and imbalance group(n=102)according to the dysbacteriosis conditions.The positive rate of neutralizing antibody,the immunoglobulin(IgG,IgA)levels,the rotavirus infection rate and the incidence of 3-year follow-up severe acute gastroenteritis(AGE)were compared between the two groups.Results:Among the 560 infants and young children,the incidence of dysbacteriosis was 18.21%(102/560).The numbers of Bifidobacteria and Lactobacilli in the normal group were greater than those in the imbalance group;the numbers of Staphylococcus aureus and Salmonella were lower than those in the disorder group;and the differences were statistically significant(P<0.05).There was no significant difference in the number of Escherichia coli between the two groups(P>0.05).The antibody positive rate of rotavirus G1,G2,G3,G4,and G9 antigens and the levels of IgG and IgA in the normal group were significantly higher than those in the imbalance group,and the differences were statistically significant(P<0.05).The rotavirus infection rate in the normal group was 1.31%(6/458),the incidence of severe AGE was 0.44%(2/458),which was significantly lower than the imbalance group of 15.69%(16/102)and 8.82%(9/102),and the differences were statistically significant(P<0.05).Conclusions:Intestinal flora imbalance affects the immune effects of the children vaccinated with rotavirus vaccine.The normal intestinal flora can help to improve the vaccine effectiveness and prevent the occurrence of rotavirus infection and severe AGEs.
作者
聂小华
NIE Xiaohua(Department of Planned Immunization of Minghu Health Service Center of the 7th People’s Hospital of Zhengzhou,Zhengzhou 450000 Henan,China)
出处
《中国民康医学》
2022年第14期117-119,共3页
Medical Journal of Chinese People’s Health
关键词
肠道菌群
轮状病毒疫苗
儿童
免疫效果
急性胃肠炎
Intestinal flora
Rotavirus vaccine
Children
Immune effect
Acute gastroenteritis
