摘要
目的:观察脉管复康胶囊联合常规西药治疗老年冠心病心力衰竭患者的效果。方法:选取2019年1月至2020年12月该院收治的110例老年冠心病心力衰竭患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各55例。对照组采用常规西药治疗,观察组在对照组基础上采用脉管康复胶囊治疗。比较两组临床疗效,治疗前后心功能指标[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]水平,炎性因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,以及不良反应发生率。结果:观察组治疗总有效率为94.55%(52/55),高于对照组的81.82%(45/55),差异有统计学意义(P<0.05);治疗后,两组LVEF水平均高于治疗前,且观察组高于对照组,两组LVEDD、LVESD水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-6、TNF-α等炎性因子水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:脉管复康胶囊联合常规西药治疗老年冠心病心力衰竭患者可提高治疗总有效率,改善心功能,以及降低炎性因子水平,效果优于单用常规西药治疗。
Objective:To observe effects of Maiguan Fukang capsules combined with conventional western medicine in treatment of elderly patients with coronary heart disease and heart failure.Methods:110 elderly patients with coronary heart disease and heart failure admitted to our hospital from January 2019 to December 2020 was selected for the prospective study,and were divided into control group and observation group according to the random number table method,55 cases in each group.The control group was treated with conventional western medicine,while the observation group was treated with Maiguan Fukang capsules on the basis of that of the control group.The clinical efficacy,the cardiac function index level[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)],the levels of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],and the incidence of adverse reactions were compared between the two groups before and after treatment.Results:The total effective rate of the observation group was 94.55%(52/55),which was higher than 81.82%(45/55)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVEF in the two groups were higher than those before the treatment,and that of the observation group was higher than that of the control group;the LVEDD and LVESD levels in the two groups were lower than those before the treatment,and those of the observation group were shorter than those of the control group;and the differences were statistically significant(P<0.05).After the treatment,the levels of CRP,IL-6,TNF-αand other inflammatory factors in the two groups were lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusi
作者
李春普
LI Chunpu(Department of Cardiovascular Medicine of Xinghua People’s Hospital,Taizhou 225700 Jiangsu,China)
出处
《中国民康医学》
2022年第14期90-92,96,共4页
Medical Journal of Chinese People’s Health
关键词
冠心病
心力衰竭
脉管康复胶囊
氢氯噻嗪
地高辛
心功能
炎性因子
不良反应
Coronary heart disease
Heart failure
Maiguan Fukang capsules
Hydrochlorothiazide
Digoxin
Cardiac function
Inflammatory factor
Adverse reaction
