摘要
目的:观察坦索罗辛联合输尿管纤维软镜碎石术治疗输尿管上段嵌顿性结石患者的效果。方法:选取2018年2月至2021年2月该院收治的80例输尿管上段嵌顿性结石患者进行前瞻性研究,按照随机数字表法将其分为观察组与对照组各40例。对照组采用输尿管纤维软镜碎石术治疗,观察组在对照组基础上联合盐酸坦索罗辛缓释胶囊治疗,比较两组术后不同时间结石排净率、治疗前后肾功能相关指标[血肌酐(SCr)、血尿素氮(BUN)、尿中性粒细胞明胶酶相关脂质运载蛋白(NGAL)]水平、术后并发症发生率、肾绞痛发生率和结石复发率。结果:术后1周,两组结石排净率比较,差异无统计学意义(P>0.05);观察组术后2、4周的结石排净率均高于对照组,差异有统计学意义(P<0.05);观察组SCr、BUN、NGAL水平均低于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05);随访6个月,两组结石复发率比较,差异无统计学意义(P>0.05);观察组术后肾绞痛发生率低于对照组,差异有统计学意义(P<0.05)。结论:坦索罗辛联合输尿管纤维软镜碎石术治疗输尿管上段嵌顿性结石患者可提高术后2、4周结石排净率,改善肾功能相关指标水平和术后肾绞痛发生率,其效果优于单纯输尿管纤维软镜碎石术治疗。
Objective:To observe effects of Tamsulosin combined with flexible ureteroscopic lithotripsy in treatment of patients with incarcerated upper ureteral stones.Methods:A prospective study of 80 patients with incarcerated upper ureteral stones admitted to our hospital from February 2018 to February 2021 was performed,and these patients were divided into observation group and control group according to the random number table method,40 cases in each.The control group was treated with flexible ureteroscopic lithotripsy,while the observation group was treated with Tamsulosin hydrochloride sustained-release capsules on the basis of that of the control group.The stone removal rates at different time after the surgery,the renal function-related index levels[serum creatinine(SCr),blood urea nitrogen(BUN),urinary neutrophil gelatinase-associated lipocalin(NGAL)]before and after the treatment,the incidence of postoperative complications,the incidence of postoperative renal colic,and the stone recurrence rate were compared between the two groups.Results:One week after the surgery,there was no significant difference in the stone clearance rate between the two groups(P>0.05).The stone clearance rates in the observation group 2 and 4 weeks after the surgery were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of SCr,BUN and NGAL in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).During the 6-month follow-up,there was no significant difference in the stone recurrence rate between the two groups(P>0.05).Further,the incidence of postoperative renal colic in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusions:Tamsulosin combined with flexible ureteroscopic lithotripsy in the treatment of the patients with incarcerated upp
作者
刘永存
LIU Yongcun(Department of Urology of Kangping County People’s Hospital,Shenyang 110500 Liaoning,China)
出处
《中国民康医学》
2022年第14期62-64,共3页
Medical Journal of Chinese People’s Health
