摘要
4-羟基-3,5-二碘苯甲酸乙酯是一种重要的医药化工中间体,广泛应用于药物和生物活性材料的制备。本文以4-羟基苯甲酸乙酯为原料,经一步碘代反应得到目标化合物。该合成方法具有操作简单、后处理简便的优势。本文对合成反应中反应介质、碘化剂的选取及碘化剂用量、反应温度等反应条件进行了优化,产品收率为93.2%,符合工业生产的要求。该方法为4-羟基-3,5-二碘苯甲酸乙酯的合成提供了有效的合成路线,也为此类化合物的研究奠定了基础。
The compound 4-hydroxy-3,5-ethyl diiobenzoate is an intermediate of pharmaceutical compounds and is also widely used in the synthesis of pharmaceutical and bioactive materials. In this paper, the target compound was obtained by substitution reaction as a raw material of 4-hydroxybenzoate. The synthesis method has the advantages of simple operation and simple post-processing. The selection of reaction media and iodizer, the dosage of iodizer, reaction temperature and other reaction conditions in the synthesis reaction are also optimized in this paper, and the product yield is 93.2%, which meets the requirements of industrial production. This method provides an effective synthetic route for the synthesis of 4-hydroxy-3,5-ethyl diiobenzoate, and also lays a foundation for the study of such compounds.
作者
彭亭森
严贵贵
杨成元
吴越友
王金康
Peng Tingsen;Yan Guigui;Yang Chengyuan;Wu Yueyou;Wang Jinkang(School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025;School of Pharmaceutical Sciences,Guizhou University,Guiyang 550025,China)
出处
《广东化工》
CAS
2022年第15期12-14,共3页
Guangdong Chemical Industry
基金
贵州大学大学生“SRT计划”项目,合同编号:贵大SRT字(2021)339号。
