摘要
Neuroblastoma is the most prevalent solid tumor seen outside of the brain in children.Despite multimodal therapy,high-risk neuroblastoma has a 5-year survival rate of less than 50%.Necroptosis,an inflammatory form of controlled cell death,has either anti-tumor or pro-tumor functions in several types of adult malignancies.However,the genes related to necroptosis and their association with prognosis in neuroblastoma are unclear.This study sought to determine the role of necroptosis-related genes in neuroblastoma a comprehensive bioinformatics analysis.Based on the expression of genes associated with necroptosis,the neuroblastoma samples were classified into three groups.We found that neuroblastoma with high necroptosis displayed promising outcomes and increased infiltration of immune cells.On the basis of the findings of the Cox regression analysis,we developed a four-gene prediction model consisting of PGAM family member 5(PGAM5),tumor necrosis factor(TNF),baculoviral IAP repeat containing 2(BIRC2),and fas associated via death domain(FADD)that is strongly linked with overall survival.The model exhibited superior performance,both internally and externally.Our data demonstrate that a high necroptosis rate correlates with favorable outcome and immune infiltration.These four necroptosis-related genes may serve as therapeutic targets,encouraging research on necroptosis in high-risk neuroblastoma therapy.
