摘要
目的观察2型糖尿病患者采取维格列汀联合二甲双胍治疗的临床效果,并分析药理。方法60例2型糖尿病患者,随机分为试验组与对照组,各30例。对照组采用二甲双胍治疗,试验组在对照组的基础上加用维格列汀治疗。比较两组临床疗效、氧化应激指标、常规血糖指标、生活质量调查表(QLQ-C30)评分、不良反应发生情况。结果试验组治疗总有效率为93.33%,高于对照组的56.67%,差异有统计学意义(P<0.05)。试验组血清活性氧类物质(571.52±22.35)IU/ml、丙二醛(44.05±3.23)nmol/ml、空腹血糖(6.30±1.02)mmol/L、餐后2 h血糖(7.42±0.53)mmol/L、糖化血红蛋白(6.12±0.1)%低于对照组的(612.09±15.39)IU/ml、(51.42±3.10)nmol/ml、(6.85±1.01)mmol/L、(8.48±0.43)mmol/L、(7.18±0.10)%,超氧化物歧化酶(276.20±10.51)IU/ml高于对照组的(254.60±11.12)IU/ml,差异有统计学意义(P<0.05)。试验组社会功能、认知功能、精神健康、躯体功能、总体健康评分分别为(80.34±3.80)、(71.36±3.12)、(56.76±3.21)、(46.32±3.21)、(48.62±3.55)分,均高于对照组的(62.19±3.70)、(55.43±3.11)、(41.02±3.43)、(33.58±4.10)、(32.66±3.53)分,差异有统计学意义(P<0.05)。试验组不良反应发生率为13.33%,低于对照组的36.67%,差异有统计学意义(P<0.05)。结论维格列汀联合二甲双胍对2型糖尿病患者效果显著,能改善患者的临床症状,值得推广。
Objective To observe the clinical effect of vildagliptin combined with metformin in patients with type 2 diabetes mellitus and analyze the pharmacology.Methods A total of 60 patients with type 2 diabetes mellitus were randomly divided into experimental group and control group,with 30 cases in each group.The control group was treated with metformin,and the experimental group was treated with vildagliptin on the basis of the control group.The clinical efficacy,oxidative stress indexes,routine blood glucose indexes,quality of life questionnaire core 30(QLQ-C30)score,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was 93.33%,which was higher than 56.67% of the control group,and the difference was statistically significant(P<0.05).In the experimental group,the serum reactive oxygen species was(571.52±22.35)IU/ml,the malondialdehyde was(44.05±3.23)nmol/ml,the fasting blood glucose was(6.30±1.02)mmol/L,the 2 h postprandial blood glucose was(7.42±0.53)mmol/L,and the glycosylated hemoglobin was(6.12±0.1)%,which were lower than(612.09±15.39)IU/ml,(51.42±3.10)nmol/ml,(6.85±1.01)mmol/L,(8.48±0.43)mmol/L,and(7.18±0.10)% in the control group;the superoxide dismutase(276.20±10.51)IU/ml was higher than(254.60±11.12)IU/ml in the control group;all the differences were statistically significant(P<0.05).The scores of social function,cognitive function,mental health,physical function,and overall health of the experimental group were(80.34±3.80),(71.36±3.12),(56.76±3.21),(46.32±3.21),and(48.62±3.55)points,which were higher than(62.19±3.70),(55.43±3.11),(41.02±3.43),(33.58±4.10),and(32.66±3.53)points of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 13.33%,which was lower than 36.67% in the control group,and the difference was statistically significant(P<0.05).Conclusion Vildagliptin combined with metformin has significant effect on patie
作者
刘晓丹
LIU Xiao-dan(Department of Pharmacy,Dalian Seventh People's Hospital,Dalian 116023,China)
出处
《中国现代药物应用》
2022年第13期139-142,共4页
Chinese Journal of Modern Drug Application
关键词
2型糖尿病
维格列汀
二甲双胍
临床效果
药理分析
Type 2 diabetes mellitus
Vildagliptin
Metformin
Clinical effect
Pharmacological analysis
