摘要
目的 研究吗啡联合右美托咪定静脉自控镇痛在晚期胃癌中度癌痛患者中的应用。方法 回顾性收集于2017年1月—2020年6月在该院行静脉自控镇痛治疗的晚期胃癌患者的临床资料进行整理、分析,根据治疗方式不同划分为研究组(n=62,吗啡联合右美托咪定治疗)和对照组(n=61,吗啡治疗)。比较二组疼痛程度[根据疼痛数字量表评分法(numerical rating scale,NRS)判定]、镇痛疗效[采用美国国立综合癌症网络(national comprehensivecancer network,NCCN)恶性肿瘤临床实践指南判定]、生活质量[采用肿瘤患者生存质量评分标准(quality of life,QOL)评定]及不良反应发生情况。结果 治疗后,二组NRS评分均有下降,且以研究组下降更为明显,差异有统计学意义(P<0.05);研究组镇痛疗效(96.77%)显著高于对照组(85.25%)(86.00%)(P<0.05);治疗后,二组QOL评分均有提高,且研究组高于对照组义(P<0.05);研究组不良反应发生率(6.45%)明显低于对照组(19.67%)(P<0.05),以上差异均有统计学意义。结论 吗啡联合右美托咪定静脉自控镇痛治疗对晚期胃癌中度癌痛患者的镇痛效果显著,能够有效减轻患者的癌痛症状;联合用药后因吗啡使用剂量减少,不良反应随之下降,安全性较高,可有效提高患者生活质量。
Objective To study the application value of morphine combined with dexmedetomidine intravenous patient-controlled analgesia in patients with advanced gastric cancer and moderate cancer pain.Methods The clinical data of patients with advanced gastric cancer treated with intravenous patient-controlled analgesia in our hospital from January 2017 to June 2020 were retrospectively collected for sorting and analysis.According to different treatment methods,they were divided into study group(n=62,morphine combined with dexmedetomidine treatment) and control group(n=61,morphine treatment).The pain[assessed by the Numerical Rating Scale(NRS)],analgesic efficacy[assessed by the clinical practice guidelines for malignant tumors in National Comprehensive Cancer Network(NCCN)],quality of life(QOL)and the occurrence of adverse reactions between the two groups were compared.Results After treatment,the NRS scores of the two groups decreased,and the decrease was more obvious in the study group,and the difference was statistically significant(P<0.05).The analgesic efficacy of the study group(96.77) was significantly higher than that of the control group(85.25%)(86.00%)(P<0.05).After treatment,the QOL scores of two groups increased,and the score of the study group was higher than that of the control group(P<0.05).The incidence of adverse reactions in the study group(6.45%) was significantly lower than that in the control group(19.67%)(P<0.05),all above differences were statistically significant.Conclusion Combined with dexmedetomidine has a significant analgesic effect on patients with moderate cancer pain in advanced gastric cancer,and can effectively alleviate the symptoms of cancer pain.After the combined medication,due to the decreasing in the dosage of morphine,the adverse reactions will decrease,and the safety is high,which can effectively improve the quality of life of patients.
作者
夏智谦
XIA Zhiqian(Department of pain,Dujiangyan People′s Hospital,Dujiangyan 611830,China)
出处
《中国煤炭工业医学杂志》
2022年第3期308-312,共5页
Chinese Journal of Coal Industry Medicine
基金
四川省卫生和计划委员会科研课题(编号:1702512)。
关键词
胃癌
吗啡
右美托咪定
静脉自控镇痛
癌痛
Gastric cancer
Morphine
Dexmedetomidine
Patient-controlled intravenous analgesia
Cancer pain
