摘要
失眠是一种最常见的睡眠障碍,其发生受神经/内分泌系统失调、环境因素和社会心理因素等多重因素的影响。长期失眠不仅会导致疲劳、注意力不集中等问题,更严重者会出现记忆衰退、情绪障碍乃至神经退行性疾病。目前的化学药物疗法存在副作用大、疗效不足等缺陷,因此亟待开发新的防治策略。近年来,随着科学界对“菌群-肠-脑”轴的深入了解,靶向肠道菌群以调控宿主昼夜节律、改善失眠引发的神经系统问题,已经取得了理论上的突破,并展示出巨大的实践价值。基于此,该文对失眠的病理学机制、肠道菌群在失眠中扮演的角色和缓解失眠的膳食策略进行梳理和总结,以期为开发新型抗失眠药物和功能食品提供参考。
Insomnia is a sort of sleep disorder,which is affected by multiple factors such as neurological/endocrine system disorders,environmental factors,and psychosocial factors.Long-term insomnia can cause chronic fatigue and lack of concentration.More seriously,it can lead to memory decline,mood disorders,and even neurodegenerative diseases.Since current chemotherapeutics have disadvantages such as adverse side effects and insufficient curative effects,it is urgent to develop new prevention and treatment strategies.In recent years,with the in-depth understanding of the microbiome-gut-brain axis,targeting the gut microbiota to regulate the host’s circadian rhythm and the nervous system shows promising flexibility.Thus,this review summarizes the pathological mechanism of insomnia,the role of the gut microbiome in insomnia,and the dietary strategies for alleviating insomnia to guide the development of new anti-insomnia drugs and functional foods.
作者
田培郡
蒋娇娜
吕天凤
王荣
王刚
陈卫
TIAN Peijun;JIANG Jiaona;LYU Tianfeng;WANG Rong;WANG Gang;CHEN Wei(School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2022年第15期303-308,共6页
Food and Fermentation Industries
基金
博士后创新人才支持计划项目(BX2021114)
国家自然基金面上项目(31972052)。
关键词
失眠
昼夜节律
菌群-肠-脑轴
益生菌
神经递质
insomnia
circadian rhythms
microbiome-gut-brain axis
probiotics
neurotransmitters
