摘要
目的探讨硝普钠联合多巴胺持泵入用于老年顽固性心衰治疗的临床效果。方法选取北京市西城区平安医院2019年9月-2020年10月收治的老年顽固性心衰患者96例,按数字随机均分法将患者分为对照组和观察组,每组48例。对照组实施硝普钠持泵入治疗,观察组实施硝普钠联合多巴胺持泵入治疗,对比两组患者治疗前后的心功能及临床指标变化情况,比较治疗后两组患者不良反应总发生率及临床治疗效果。结果治疗前,两组患者的左室射血分数(LVEF)、左室舒张末期内经(LVDd)及左室收缩末期内经(LVDs)差异无统计学意义(t=0.251、0.126、0.052,P>0.05);治疗后,观察组LVEF高于对照组,LVDd及LVDs值均明显低于对照组,差异有统计学意义(t=4.612、2.934、5.447,P<0.05)。治疗前,两组患者的舒张压、收缩压、呼吸频率及心率差异无统计学意义(t=0.185、0.328、0.436、0.426,P>0.05)。治疗后,观察组患者的舒张压、收缩压、呼吸频率及心率均明显低于对照组,差异有统计学意义(t=4.341、9.741、7.378、19.560,P<0.05)。观察组不良反应总发生率(8.33%)明显低于对照组(20.83%),但差异无统计学意义(χ^(2)=3.010,P>0.05)。观察组临床治疗效果(95.83%)明显优于对照组(70.83%),差异有统计学意义(χ^(2)=10.800,P<0.05)。结论硝普钠联合多巴胺持泵入治疗老年顽固性心衰可明显改善患者的心功能及临床症状指标,降低不良反应发生率,临床疗效显著。
Objective To investigate the clinical effect of sodium nitroprusside combined with dopamine sustained pump in the treatment of elderly patients with refractory heart failure.Methods 96 elderly patients with intractable heart failure treated in Ping'an Hospital of Xicheng District of Beijing City from September 2019 to October 2020 were selected.The patients were randomly divided into control group and observation group,with 48 cases in each group.The control group was treated with sodium nitroprusside and the observation group was treated with sodium ni⁃troprusside combined with dopamine.The changes of cardiac function and clinical indexes of the two groups before and after treatment were compared,and the total incidence of adverse reactions and clinical treatment effect of the two groups after treatment were compared.Results Before treatment,there was no statistically significant difference in the left ventricular ejection fraction(LVEF),left ventricular end-diastolic menstruation(LVDd)and left ventricu⁃lar end-systolic menstruation(LVDs)between the two groups(t=0.251,0.126,0.052,P>0.05).After treatment,LVEF in the observation group was higher than that in the control group,the values of LVDd and LVDS were significantly lower than those in the control group,the difference was statistically significant(t=4.612,2.934,5.447,P<0.05).Before treatment,there was no statistically significant difference in diastolic blood pressure,systolic blood pressure,respiratory rate and heart rate between the two groups(t=0.185,0.328,0.436,0.426,P>0.05).After treat⁃ment,the diastolic blood pressure,systolic blood pressure,respiratory rate and heart rate in the observation group were significantly lower than those in the control group,the difference was statistically significant(t=4.341,9.741,7.378,19.560,P<0.05).The total incidence of adverse reactions in the observation group(8.33%)was significantly lower than that in the control group(20.83%),but the difference was not statistically significant(χ^(2)=3.010,P>0.05).The clini
作者
张辉
ZHANG Hui(Department of Internal Medicine,Ping'an Hospital,Xicheng District,Beijing,100035 China)
出处
《系统医学》
2022年第12期111-114,共4页
Systems Medicine
关键词
硝普钠持泵
多巴胺持泵
老年顽固性心衰
临床效果
Sodium nitroprusside pump
Dopamine pump
Elderly refractory heart failure
Clinical effect
