摘要
目的探讨影响结肠直肠癌患者术后健康相关生活质量(health-related quality of life,HRQoL)的危险因素,从而通过控制危险因素改善结肠直肠癌术后患者的预后和生活质量。方法前瞻性连续队列纳入2019年5~6月结肠癌术后患者212例,收集纳入队列患者的性别、年龄、吸烟状况、体重指数、麻醉分级、急症手术、手术方式、肿瘤分期的数据,利用EORTC生命质量测定量表(V3.0)测定收集健康相关生活质量(HRQoL)的数据,利用R语言多重插补法处理缺失数据,利用多元logistic回归处理可能的影响因素:性别、年龄、吸烟状况、体重指数、麻醉分级、急症手术、手术方式、肿瘤分期,利用相对危险度计算出影响健康相关生活质量的危险因素。结果共计入选结直肠癌患者212例,其中157例(74%)被纳入数据分析,男82例占52.2%,平均年龄54(44,64)岁。6个月随访中具有吸烟,麻醉分级(3~4级),体重指数不正常,高龄,肿瘤分期Ⅳ期,造漏手术的危险因素的患者预示着更低的健康相关生活质量。结论研究结果可以对结直肠癌术后患者的健康相关生活质量提供更加个体化关注,对改善其健康相关生活质量提供帮助。
Objective To study of risk factors for low health-related quality of life(HRQoL)in postoperative colorectal cancer patients,thereby improving their prognosis and QoL.Methods This is a prospective continuous cohort study.Totally 212 postoperative colorectal cancer patients were enrolled between May and June in 2019.The data of these patients including gender,age,smoking habits,body mass index(BIM),anesthesia classification(ASAC),emergency surgery,surgical approach,tumor staging were collected.The European Organisation for Treatment and Research of Cancer(EORTC)Quality of Life Questionnaire(QLQ-C30)were used to assess the HRQoL data.The missing data were processed with multiple interpolation method of R Language.Multivariate logistic regression was performed to analyze possible factors affecting HRQoL of these data.Results A total of 212 colon cancer patients were included,of which 157(74%)met the data analysis,including 82 males(52.2%)with an average age of 54(44,64)years.During the 6-month follow-up,it was the risk factors that smoking habits,ASAC(3~4),abnormal BMI,senility,tumor stagingⅣand fistulation,suggesting lower HRQoL.Conclusion The findings are eligible to be used to provide more individualized attention to the HRQoL of colorectal cancer patients and to help improve their HRQoL.
作者
白峰
杨剑飞
张小雷
刘亚彬
BAI Feng;YANG Jianfei;ZHANG Xiaolei(不详;Department of Surgery,Hebei Chest Hospital,Shijiazhuang 050041,China)
出处
《河北医药》
CAS
2022年第15期2380-2384,共5页
Hebei Medical Journal
基金
河北省卫生健康委员会科研课题(编号:20180558)。
关键词
健康相关生活质量
结直肠癌
造瘘术
吸烟
回归分析
health related quality of life(HRQoL)
colorectal cancer
fistulation
smoking
regression analysis
