摘要
目的分析表皮生长因子受体(EGFR)和细胞周期蛋白D1(Cyclin D1)在喉癌组织中的表达及其与预后的相关性。方法选取46例原发性喉鳞状细胞癌组织标本作为研究组,20例声带息肉组织标本作为对照组。使用免疫组化染色检测所有组织中EGFR和Cyclin D1的表达水平,分析2组基因表达水平之间的关系,以及喉癌患者临床资料与基因表达水平的关系。使用比例风险回归模型评估EGFR和Cyclin D1及相关临床资料与患者生存率的相关性。结果EGFR和Cyclin D1在喉癌组织中的表达率分别为71.7%和52.2%,在声带息肉组织中的表达率分别为10.0%和5.0%。EGFR和Cyclin D1的表达水平与喉癌患者生存率相关。比例风险回归模型分析表明,较高的TNM分期是患者预后不良的独立危险因素。结论EGFR和Cyclin D1的高表达促进了喉癌细胞的侵袭和转移,二者能够协同参与喉癌的发生发展,且EGFR和Cyclin D1在喉癌组织中的表达与患者生存率相关。
Objective To analyze the expression of epidermal growth factor receptor(EGFR)and Cyclin D1 in laryngeal carcinoma and their correlation with prognosis.Methods 46 specimens of primary laryngeal squamous cell carcinoma diagnosed and treated were selected as the study group,and 20 specimens of vocal cord polyp tissue were selected as the control group.Immunohistochemical staining was used to detect the expression levels of EGFR and Cyclin D1 in all tissues,and to analyze the relationship between the 2 groups of gene expression levels,and the relationship between the clinical data and gene expression levels of patients with laryngeal cancer.A proportional hazard regression model was used to evaluate the correlation between EGFR and Cyclin D1 and related clinical data on the prognosis of patients.Results The expression rates of EGFR and Cyclin D1 were 71.7%and 52.2%in laryngeal carcinoma and 10.0%and 5.0%in vocal cord polyps,respectively.The expression levels of EGFR and Cyclin D1 were correlated with the prognosis of patients with laryngeal cancer.Proportional hazards regression analysis showed that higher TNM stage was an independent risk factor.Conclusion The high expression of EGFR and Cyclin D1 promotes the invasion and metastasis of laryngeal cancer cells.They can cooperate in the occurrence and development of laryngeal cancer.The expression of EGFR and Cyclin D1 in laryngeal cancer is related to the prognosis of patients.
作者
杨庆军
YANG Qingjun(Zhoukou Central Hospital,Zhoukou,466000)
出处
《实用癌症杂志》
2022年第8期1237-1240,共4页
The Practical Journal of Cancer
