摘要
目的:分析早期连续肾脏替代疗法(CRRT)对严重腹腔感染(IAI)患者炎性反应及预后的影响。方法:选取2020年1月-2022年1月佛山市高明区人民医院住院的80例严重IAI患者,依随机数表法分组,各40例,对照组给予常规治疗,观察组在对照组基础上给予CRRT治疗,对比两组治疗效果。结果:观察组临床总有效率高于对照组,差异具有统计学意义(χ2=8.658,P=0.003)。观察组治疗3 d、7 d后降钙素原(PCT)、白细胞计数(WBC)均低于对照组,差异有统计学意义(P<0.05)。两组治疗前序贯器官衰竭评分(SOFA)、急性生理学和慢性健康状况评价(APACHEⅡ)评分比较,差异无统计学意义(P<0.05);观察组治疗3 d、7 d后SOFA评分及APACHEⅡ评分均比对照组低,差异具有统计学意义(P<0.05)。观察组ICU入住时间、总住院时间均短于对照组,差异具有统计学意义(t=8.837、6.871,P均<0.05);观察组病死率低于对照组,差异具有统计学意义(χ2=4.505,P=0.034)。结论:严重IAI患者采纳早期CRRT治疗,可有效减轻患者机体炎性反应,改善身体健康状况,缩短治疗时间,降低病死率。
Objective:To analyze the effect of early continuous renal replacement therapy(CRRT)on the inflammatory reaction and prognosis of patients with severe intra-abdominal infection(IAI).Methods:A total of 80 patients with severe IAI who were hospitalized in Gaoming District People's Hospital of Foshan City from January 2020 to January 2022 were selected and divided into groups according to the random number table method,with 40 cases in each group.The control group was given routine treatment,and the observation group was given CRRT on the basis of the control group.The treatment effects of the two groups were compared.Results:The clinical total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(χ2=8.658,P=0.003).The procalcitonin(PCT)and white blood cell count(WBC)of the observation group after 3 days and 7 days of treatment were lower than those of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the sequential organ failure assessment(SOFA)score and acute physiology and chronic health evaluation(APACHE)score between the two groups before treatment(P<0.05).The SOFA score and APACHE II score of the observation group after 3 days and 7 days of treatment were lower than those of the control group,and the difference was statistically significant(P<0.05).The ICU stay time and total hospital stay in the observation group were shorter than those in the control group,and the difference was statistically significant(t=8.837,6.871,both P<0.05).The mortality rate of the observation group was lower than that of the control group,and the difference was statistically significant(χ2=4.505,P=0.034).Conclusion:Early CRRT treatment for severe IAI patients can effectively reduce the inflammatory reaction of the patient's body,improve physical health,shorten the treatment time,and reduce mortality.
作者
马俊
余庆华
黎智宾
唐小霞
Ma Jun;Yu Qing-hua;Li Zhi-bin;Tang Xiao-xia(Department of Critical Care Medicine,Gaoming District People's Hospital of Foshan City,Foshan 528500,Guangdong Province,China)
出处
《中外医药研究》
2022年第1期18-20,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
连续肾脏替代疗法
严重腹腔感染
炎性反应
Continuous renal replacement therapy
Severe intra-abdominal infection
Inflammatory reaction
