摘要
芝麻素是重要的木脂素类化合物,主要从芝麻籽中分离出来,具有抗氧化应激、抗炎、抗凋亡、减少Aβ聚集、抗兴奋性毒性、促进多巴胺生成和神经营养因子表达等多种生物活性,可在动物及细胞水平上有效预防和治疗阿尔茨海默病、帕金森病、创伤性脑损伤、抑郁焦虑、脑缺血损伤及其它神经精神疾病。本文对芝麻素体内外实验中的神经保护作用及相关机制进行综述,以期为芝麻素相关保健品、食品添加剂的开发应用提供科学依据。
Sesamin is an important lignan compound, which is mainly isolated from sesame seeds. Sesamin has a variety of biological activities such as anti-oxidative stress, anti-inflammatory, anti-apoptosis, reducing β-amyloid aggregation, antiexcitatory toxicity, promoting dopamine production and neurotrophic factor expression. Sesamin can effectively prevent and treat Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, depression and anxiety, cerebral ischemia injury and other neuropsychiatric diseases at the animal and cellular levels. In this paper, the neuroprotective effects and related mechanisms of sesamin in vivo and in vitro experiments are reviewed in order to provide scientific basis for the development and application of sesamin-related health care products and food additives.
作者
蒋德旗
莫娟凤
宾水连
陀银婷
李子强
李欣怡
梁瑞兰
JIANG Deqi;MO Juanfeng;BIN Shuilian;TUO Yinting;LI Ziqiang;LI Xinyi;LIANG Ruilan(College of Biology and Pharmacy,Yulin Normal University,Yulin 537000,China;Bioengineering&Technology Center for Native Medicinal Resources Development,Yulin Normal University,Yulin 537000,China;Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology,Yulin 537000,China)
出处
《食品工业科技》
CAS
北大核心
2022年第16期452-457,共6页
Science and Technology of Food Industry
基金
广西自然科学基金(2021GXNSFAA220001,2018GXNSFAA050002)
玉林市科学研究与技术开发计划项目(玉市科能20194304)
广西大学生创新创业训练计划项目(202110606157)。
关键词
芝麻素
氧化应激
抗炎
阿尔茨海默病
神经保护
sesamin
oxidative stress
anti-inflammatory
Alzheimer’s disease
neuroprotective
