摘要
目的:探究消旋山莨菪碱联合依替米星、间苯三酚在急性肠胃炎痉挛性腹痛患者中的应用效果。方法:选取2017年1月至2020年12月惠安县医院急诊科收治的急性肠胃炎痉挛性腹痛患者200例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组100例。对照组给予依替米星、间苯三酚治疗,观察组给予消旋山莨菪碱联合依替米星、间苯三酚治疗,观察2组患者症状缓解时间、疼痛改善情况、炎症介质水平、不良反应以及睡眠质量。结果:观察组的症状缓解时间均短于对照组,2组比较差异均有统计学意义(均P<0.05)。观察组治疗后1 h、24 h、48 h、72 h的匹兹堡睡眠质量指数(PSQI)评分、疼痛视觉模拟评分法(VAS)评分均低于对照组,2组比较差异均有统计学意义(均P<0.05)。治疗后,2组患者的IL-6、IL-8水平均降低(均P<0.05),且观察组低于对照组,2组比较差异均有统计学意义(均P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:消旋山莨菪碱联合依替米星、间苯三酚在急性肠胃炎痉挛性腹痛患者中应用效果良好。
Objective:To explore the application effect of raceanisodamine combined with etimicin and phloroglucinol in patients with spasmodic abdominal pain induced by acute gastroenteritis.Methods:A total of 200 patients with spasmodic abdominal pain induced by acute gastroenteritis admitted to the hospital were enrolled between January 2017 and December 2020.According to random number table method,they were divided into observation group(100 cases)and control group(100 cases).The control group was treated with etimicin and phloroglucinol,while observation group was additionally treated with raceanisodamine.The symptom relief time,pain relief,inflammatory mediators,adverse reactions and sleep quality of the two groups were observed.Results:The symptom relief time of the observation group was shorter than that of the control group(P s<0.05).At 1 h,24 h,48 h and 72 h after treatment,the Pittsburgh Sleep Quality Index(PSQI)scores and visual analogue scale(VAS)scores of the observation group were lower than those of the control group(P s<0.05).After treatment,the levels of IL-6 and IL-8 were reduced in the two groups(P s<0.05),which were lower in the observation group than in the control group(P s<0.05).There was no significant difference in the incidence of adverse reactions between observation group and control group(P>0.05).Conclusion:Raceanisodamine combined with etimicin and phloroglucinol can achieve good effects in patients with spasmodic abdominal pain induced by acute gastroenteritis.
作者
黄烽
HUANG Feng(Emergency Department,Hui′an County Hospital,Hui′an 362100,China)
出处
《世界睡眠医学杂志》
2022年第6期1033-1035,共3页
World Journal of Sleep Medicine
