摘要
肿瘤已成为当前威胁人类健康的主要疾病之一。肿瘤的常规疗法不良反应大,且易产生耐药性,新型疗法价格昂贵,给患者造成沉重负担。中医药治疗肿瘤效果确切,中药内含有多种天然活性成分,许多临床常用抗肿瘤药物来源于中药。中药多糖广泛存在于多种中草药当中,易于提取制备,具有抗肿瘤、抗病毒、抗氧化等多种天然活性。研究表明,中药多糖抗肿瘤作用显著,具有多角度、多机制协同的特点,可避免产生耐药性,是具有极大研究价值和开发潜力的抗肿瘤新药。其抗肿瘤分子机制主要包括抑制肿瘤增殖、促肿瘤凋亡、诱导自噬、影响细胞周期、抑制肿瘤血管生成、调节上皮间质转化(EMT)、促肿瘤氧化应激、调节免疫及调控磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、Toll样受体4(TLR4)、丝裂原活化蛋白激酶/核转录因子-κB(MAPK/NF-κB)、血管老化单磷酸腺苷活化蛋白激酶/哺乳动物雷帕霉素靶蛋白(AMPK/mTOR)、表皮生长因子受体/细胞外信号调节激酶(EGFR/ERK)、p53以及Wnt/β-连环蛋白(Wnt/β-catenin)信号通路等方面。
Tumor has become one of the major diseases threatening human health at present.Conventional therapies for tumor have serious side effects and are prone to drug resistance,while new therapies are expensive and impose a heavy burden on patients.Chinese herbs effective in the treatment of tumor contain a variety of natural active ingredients,and many anti-tumor drugs used in clinical practice are derived from Chinese herbs.Polysaccharides,ubiquitous in Chinese herbs,are easy to extract and have antitumor,antiviral,and antioxidant activities.Studies have demonstrated that the polysaccharides from Chinese herbs have significant anti-tumor effect and are characterized by multi-target and multi-mechanism functioning,which can avoid the development of drug resistance,exhibiting a great research value and the potential to be developed into novel anti-tumor drugs.Their anti-tumor mechanisms mainly include the inhibition of tumor proliferation,promotion of apoptosis,induction of autophagy,influence on cell cycle,inhibition of tumor angiogenesis,modulation of epithelial-mesenchymal transition(EMT)and immunity,promotion of tumor oxidative stress,and regulation of phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),Toll-like receptor 4(TLR4),mitogen-activated protein kinase/nuclear factor-kappa B(MAPK/NF-κB),adenosine 5'-monophosphate(AMP)-activated protein kinase/mechanistic target of rapamycin(AMPK/mTOR),epidermal growth factor receptor/extracellular signal-regulated kinase(EGFR/ERK),p53,and Wnt/β-catenin signaling pathways.
作者
周艾玲
王段珩
岳晓蕾
周崇
黄莉
ZHOU Ailing;WANG Duanheng;YUE Xiaolei;ZHOU Chong;HUANG Li(Guangxi University of Chinese Medicine,Nanning 530200,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2022年第16期236-244,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81860539)
广西中药药效研究重点实验室开放课题项目(20-065-38)。
关键词
中药
多糖
抗肿瘤
机制
信号通路
Chinese herbs
polysaccharides
anti-tumor effect
mechanisms
signaling pathways
