摘要
迟发性性腺功能减退症(LOH)是一种年龄相关的睾酮缺乏综合征。随着社会老龄化的日益加剧,LOH已严重影响中老年男性的生活质量。尽管近年来国内外诊疗指南陆续发布,LOH的管理策略逐渐规范,但在诊断标准、睾酮替代治疗(TRT)的利弊以及治疗目标等方面仍存在较多争议。本文将在比较各版指南的基础上,对LOH的年龄界限、特异性症状及体征、睾酮的诊断切点、TRT治疗的获益以及非睾酮治疗等方面进行详细讨论。
Late-onset hypogonadism(LOH)is an age-related testosterone deficiency syndrome.With the increasing aging of society,LOH results in impaired quality of life of middle-aged and elderly men.Although domestic and international guidelines have been issued in recent years,and the management of LOH became more standardized,numerous controversies still remained in the diagnosis of LOH,the benefits of testosterone replacement therapy(TRT)and therapeutic targets.Based on comparison of different guidelines,this review focuses on age cut-off,specific signs and symptoms of LOH,diagnostic cut-off level of testosterone,the advantages and disadvantages of TRT treatment,and non-testosterone therapy.
作者
胡欣
韩雪
相萍萍
何志伟
陈国芳
刘超
Hu Xin;Han Xue;Xiang Pingping;He Zhiwei;Chen Guofang;Liu Chao(Department of Endocrinology,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China)
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2022年第5期364-368,共5页
Chinese Journal of Endocrinology and Metabolism
关键词
迟发性性腺功能减退症
诊断标准
睾酮替代治疗
非睾酮治疗
Late-onset hypogonadism
Diagnosis
Testosterone replacement therapy
Non-testosterone treatment
