摘要
目的探讨津力达颗粒联合利拉鲁肽对胰岛素泵强化效果欠佳2型糖尿病的临床疗效及血脂和内皮素1(En-dothelin-1,ET-1)的影响。方法研究对象来源于2018年7月—2021年10月经胰岛素泵强化效果欠佳的2型糖尿病患者60例,依据随机编号法分入对照组和联合组各30例。对照组采用利拉鲁肽;联合组采用津力达颗粒联合利拉鲁肽,持续用药3个月。治疗前和治疗3个月抽血测定餐前血糖(FBG)、餐后2 h血糖(PBG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、内皮素-1(ET-1)、一氧化氮(NO)水平。治疗3个月后评价两组的临床疗效,记录不良反应状况。结果与治疗前比,两组治疗3个月FBG、PBG、HbA1c和HOMA-IR水平均下降,而且联合组治疗3个月FBG、PBG、HbA1c和HOMA-IR水平低于对照组,差异有统计学意义(P<0.05)。与治疗前比,两组治疗3个月血清TC、TG、LDL-C水平均下降,血清HDL-C升高;联合组治疗3个月血清TC、TG、LDL-C水平低于对照组,血清HDL-C高于对照组,差异有统计学意义(P<0.05)。与治疗前比,两组治疗3个月血清ET-1水平下降,血清NO水平升高;联合组治疗3个月血清ET-1水平低于对照组,血清NO水平高于对照组,有统计学意义(P<0.05)。对照组的总有效率(80.00%,24/30)低于联合组(96.67%,29/30),差异有统计学意义(P<0.05)。两组患者不良反应率比较,差异无统计学意义(P>0.05)。结论津力达颗粒联合利拉鲁肽可以进一步提高胰岛素泵强化效果欠佳2型糖尿病的临床疗效,改善糖脂代谢和内皮细胞功能,安全性高,值得大力推广。
Objective To investigate the effect of Jinlida Granule(津力达颗粒)combined with Liraglutide Injection on the clinical efficacy and blood lipid and endothelin-1(ET-1)of type 2 diabetes mellitus with poor insulin pump effect.Meth-ods Sixty patients with type 2 diabetes who were poorly treated with insulin pump from July 2018 to 2021 were divided into the control group and the combined group,according to the random number method,with 30 cases in each group.The control group was treated with Liraglutide Injection.The combined group was treated with Jinlida Granule combined with Liraglutide Injection for 3 months.Blood samples were taken before and 3 months after treatment to measure the levels of pre meal blood glucose(FBG),2 h postprandial blood glucose(PBG),glycosylated hemoglobin(HbA1c),insulin resistance index(HOMA-IR),total cholesterol(TC),triglyceride(TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),ET-1 and nitric ox-ide(NO).After 3 months of treatment,the clinical efficacy of the two groups was evaluated and the adverse reactions were recor-ded.Results Compared with those before treatment,the levels of FBG,PBG,HbA1c and HOMA-IR in the two groups were de-creased after 3 months of treatment,and the levels of FBG,PBG,HbA1c and HOMA-IR in the combined group were significantly lower than those in the control group after 3 months of treatment(P<0.05).Compared with those before treatment,the levels of serum TC,TG and LDL-C were decreased and the level of serum HDL-C was increased in the two groups after 3 months of treatment.After 3 months of treatment,the levels of serum TC,TG and LDL-C in the combined group were lower than those in the control group,and the level of serum HDL-C was higher than that in the control group(P<0.05).Compared with those be-fore treatment,the level of serum ET-1 was decreased and the level of serum NO increased in the two groups after 3 months of treatment.After 3 months of treatment,the level of serum ET-1 in the combined group was lower than that in the control gr
作者
赵正历
房根强
耿建林
ZHAO Zhengli;FANG Genqiang;GENG Jianlin(Hengshui People's Hospital,Hengshui 053000,Heibei,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第6期242-246,共5页
Chinese Archives of Traditional Chinese Medicine
基金
河北省医学科学研究重点课题计划(20171214)
衡水市科技局研究项目(2018014024Z)。
关键词
津力达颗粒
利拉鲁肽
胰岛素泵强化效果欠佳
2型糖尿病
血脂
内皮细胞功能
Jinlida Granule(津力达颗粒)
liraglutide
poor insulin pump effect
type 2 diabetes mellitus
blood lipids
endo-thelial cell function
