摘要
目的探讨针灸联合推拿及康复疗法对卒中后四肢功能障碍患者血清环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)、神经运动功能及生活质量的影响。方法选取诊治的卒中后四肢功能障碍患者80例,随机分为对照组与观察组,每组40例,对照组采用推拿及康复疗法治疗,观察组采用针灸联合推拿及康复疗法治疗,疗程3个月,观察治疗前后血清cAMP及cGMP变化,采用美国国立卫生研究院卒中量表(NIHSS)及临床神经功能缺损程度量表(CSS)对神经功能进行评估,采用简化Fugl-Meyer运动功能量表(FMA)对运动功能进行评估,采用Berg平衡量表(BBS)对患者平衡能力进行评估,采用生活质量量表(QOL-100)量表及脑卒中专用生活质量量表(SS-QOL)对患者生活质量进行评估。结果两组患者治疗前血清cAMP及cGMP水平比较差异无统计学意义(P>0.05),治疗后cAMP较治疗前升高(P<0.05),且观察组升高程度大于对照组(P<0.05),cGMP较治疗前下降(P<0.05),观察组下降幅度大于对照组(P<0.05);两组患者治疗前NIHSS、CSS、FMA、BBS评分比较差异无统计学意义(P>0.05),治疗后NIHSS、CSS较治疗前降低(P<0.05),且观察组降低程度大于对照组(P<0.05),FMA、BBS评分较治疗前升高(P<0.05),且观察组升高幅度大于对照组(P<0.05);两组患者治疗前QOL-100、SS-QOL评分比较差异无统计学意义(P>0.05),治疗后QOL-100、SS-QOL评分较治疗前升高(P<0.05),且观察组升高幅度大于对照组(P<0.05)。结论卒中后四肢功能障碍患者在推拿及康复疗法基础上联合针灸治疗可有效促进患者神经运动功能的恢复,改善患者生活质量,其机制可能与调节cAMP及cGMP水平有关。
Objective To investigate the effects of acupuncture combined with Tuina and rehabilitation therapy on serum cyclic adenosine monophosphate(cAMP)and cyclic guanosine monophosphate(cGMP),neural function and motor function and quality of life in patients with limb dysfunction after stroke.Methods We collected 80 cases with limb dysfunction after stroke.They were randomly divided into the control group and the observation group,40 cases in each group.The control group was treated with Tuina and rehabilitation therapy and the observation group was treated with acupuncture combined with Tuina and rehabilitation therapy.The treatment course lasted for 3 months.The changes of cAMP and cGMP before and after treatment were observed and the neurological function was assessed by using the National Institutes of Health Stroke Scale(NIHSS)and Clinical Neurological Deficit Scale(CSS).The simplified Fugl-Meyer Motor Function Scale(FMA)was used to evaluate the motor function.The Berg Balance Scale(BBS)was used to evaluate patients'balance ability and the Quality of Life(QOL-100)and Stroke Quality of Life(SS-QOL)were used to evaluate the quality of life.Results There were no significant difference in levels of cAMP or cGMP in serum between two groups before treatment(P>0.05).The level of cAMP was increased after treatment compared with that before treatment(P<0.05),and the degree of increase in the observation group was greater than that in the control group(P<0.05).The level of cGMP was decreased after treatment compared with that before treatment(P<0.05),and the degree of decrease in the observation group was greater than that in the control group(P<0.05).There were no significant difference in NIHSS,CSS,FMA or BBS scores between two groups before treatment(P>0.05).The NIHSS and CSS scores were decreased af-ter treatment compared with those before treatment(P<0.05),and the degree of decrease in the observation group was greater than that in the control group(P<0.05).The FMA and BBS scores were increased after treatment compared
作者
方盛
颜平康
时宽
FANG Sheng;YAN Pingkang;SHI Kuan(The Second Hospital of Jinhua,Jinhua 321000,Zhejiang,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第6期100-103,共4页
Chinese Archives of Traditional Chinese Medicine
基金
中华医学会临床医学科研专项基金(190100935713)。
关键词
针灸
卒中
四肢功能障碍
推拿
康复疗法
环磷酸腺苷
环磷酸鸟苷
神经功能
运动功能
生活质量
acupuncture
stroke
limb dysfunction
Tuina
rehabilitation therapy
cyclic adenosine phosphate
cycloguanosine phosphate
neural function
motor function
quality of life
