摘要
N-甲基腺苷(m^(6)A)是真核生物中含量最丰富的表观遗传修饰,在哺乳动物生长发育和疾病控制中起着至关重要的作用。无论生理或者病理状态下,m^(6)A修饰均可以对骨骼发育重塑相关的基因表达进行精准调控,进而影响骨代谢平衡。该文总结了m^(6)A修饰在成骨分化过程中的调控机制,为促进骨形成和预防治疗骨代谢相关疾病提供新思路和潜在靶点。
N~6-methyladenosine(m^(6)A)is the most abundant epigenetic modification in eukaryotes and plays a significant regulatory role in mammalian growth and disease control.Studies have found that m^(6)A modification can accurately regulate the gene expression related to bone remodeling and development no matter in a physiological or pathological state,thus affecting bone metabolism balance.In this systematic review,we summarized regulatory mechanisms of m^(6)A modification in osteogenic differentiation,in order to provide new ideas and potential targets for promoting bone formation and preventing or treating diseases related to bone metabolism.
作者
张校晨
孙唯夫
方世殊
秦文
金作林
ZHANG Xiaochen;SUN Weifu;FANG Shishu;QIN Wen;JIN Zuolin(State Key Laboratory tyf Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center far Oral Diseases,Department of Orthodontics,School of Stomatology,Air Force Military Medical University,Xi'an 710032,China)
出处
《口腔医学》
CAS
2022年第7期655-658,共4页
Stomatology
基金
国家自然科学基金(81970960)。
关键词
m^(6)A修饰
RNA甲基化
成骨分化
调控机制
m^(6)A modification
RNA methylation
osteogenic differentiation
regulatory mechanism
