摘要
目的:探讨尼非卡兰对阵发性房颤患者转复情况、复律时间及心室率变化的影响。方法:选取2019年1—12月于佳木斯市中心医院接受治疗的85例阵发性房颤患者作为研究对象,依据随机数表法将入选者分为对照组(42例)、观察组(43例)。对照组采用常规治疗,观察组采用尼非卡兰治疗,观察两组患者转复情况及复律时间,记录两组患者治疗前和治疗3个月后心室率变化与心功能水平,统计两组患者不良反应发生情况。结果:观察组患者转复时间及复律时间均短于对照组,差异有统计学意义(t=2.119、3.134,P<0.05);治疗1个月后,两组患者心室率均低于治疗前(t=43.648、43.613,P<0.05),但观察组心室率与对照组比较,差异无统计学意义(t=0.435,P>0.05);治疗前两组患者心功能水平的比较,差异无统计学意义(t=0.696、1.763、0.079、1.046、0.610,P>0.05);治疗1个月后,两组患者左心射血分数(LVEF)水平高于治疗前,左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)水平低于治疗前,治疗后观察组LVEF、LVEDD、LVESD、LVESV、LVEDV水平与对照组比较,差异无统计学意义(t=1.249、1.118、1.743、1.801、0.569,P>0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(χ^(2)=0.121,P>0.05)。结论:阵发性房颤患者采用尼非卡兰治疗可有效缩短患者转复时间及复律时间,改善患者心室率变化,且不会增加不良反应,不影响心功能。
Objective:To investigate the effects of nifekaran on cardioversion,cardioversion time and ventricular rate in pa⁃tients with paroxysmal atrial fibrillation.Methods:A total of 85 patients with paroxysmal atrial fibrillation who received treatment in the hospital from January 2019 to December 2019 were selected as the research objects,and the selected patients were divided into the control group(42 cases)and the observation group(43 cases)according to the random number table method.The control group was treated with routine treatment and the observation group was treated with nifekaran.The conversion and cardioversion time of the two groups were observed.The changes of ventricular rate and cardiac function before and 3 months after treatment were recorded,and the incidence of adverse reactions in the two groups were counted.Results:The conversion time and cardiover⁃sion time of the observation group were shorter than those of the control group,and the difference was statistically significant(t=2.119,3.134,P<0.05).After 1 month of treatment,the ventricular rates of the two groups were lower than those before treatment,and the difference was statistically significant(t=43.648,43.613,P<0.05).However,there was no statistically significant difference in ventricular rate between the observation group and the control group(t=0.435,P>0.05).Before treatment,there was no statistically significant difference in cardiac function between the two groups(t=0.696,1.763,0.079,1.046,0.610,P>0.05).After 1 month of treatment,the levels of left ventricular ejection fraction(LVEF)in the two groups were higher than those before treatment,and the left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular end-systolic volume(LVESV),and left ventricular end-diastolic volume(LVEDV)levels were lower than before treatment.After treatment,there was no statistically significant difference in the levels of LVEF,LVEDD,LVESD,LVESV and LVEDV between the observation group and the control group(t=
作者
卢冬雪
何琦
LU Dong-xue;HE Qi(Department of Cardiology,Jiamusi Central Hospital,Jiamusi,Heilongjiang,154002,China)
出处
《黑龙江医学》
2022年第14期1704-1706,共3页
Heilongjiang Medical Journal
关键词
阵发性房颤
尼非卡兰
转复情况
复律时间
心室率变化
心功能
Paroxysmal atrial fibrillation
Neficaran
Reversion
Cardioversion time
Ventricular rate change
Cardiac function
