摘要
目的分析临床病理检查结果在胃肠黏膜相关淋巴组织(MALT)淋巴瘤患者中的表现。方法本次研究对象共30例,皆为我院在2010年5月至2014年10月收治的MALT淋巴瘤患者。回顾分析受试患者基本情况,包括基础资料以及病变位置、疾病分型、组织学结果、免疫组化染色分析病理结果情况。结果在30例MALT淋巴瘤患者中男性较多,平均年龄为(41.60±2.50)岁,平均发病时间为(19.50±2.50)个月。患者无特异性临床表现,主要临床症状为腹部包块及消化道不适。病变位置,疾病类型大体区分,弥漫型、溃疡型、息肉型3类。30例患者中,18例疾病为息肉型,8例为溃疡型,4例为浸润型。测量肿块直径为1.4~16.8 cm。13例患者肿瘤于胃部原发,另外17例患者疾病原发于肠道。临床病理学分析结果表明,8例为低度恶性,剩下22例为高度恶性,具有小或中等肿瘤细胞,存在不规则、致密深染细胞核形。将免疫组化染色应用于16例患者组织标本中,其中B细胞性淋巴瘤有15例。对其中13例予以随访,生存时间在5年以上的患者有10例。结论作为临床病理特征具有特异性的肿瘤之一,MALT淋巴瘤的发病可能与HP感染存在相关性,以B淋巴细胞起源为主,与胃肠癌相比MALT淋巴瘤具有更好的预后。
Objective To analyze the clinical pathological findings in patients with gastrointestinal mucosa associated lymphoid tissue(MALT lymphoma.Methods A total of 30 patients in this study,all of whom were patients with MALT lymphoma who were admitted to our hospital between May 2010 and October 2014.A retrospective analysis of the conditions of the tested patients,including basic data and lesion location,disease type,histological results,immunohistochemical staining analysis of pathological results.Results There were more males in this patient with gastrointestinal mucosa-associated lymphoid tissue lymphoma.The mean age was(41.60±2.50)years,and the mean time of onset was(19.50±2.50)months.The patient has no specific clinical manifestations,and the main clinical symptoms are abdominal mass and digestive tract discomfort.The location of the lesion and the type of disease are roughly divided into three categories:diffuse,ulcer,and polyp.Among the 30 patients,18 were polyps,8were ulcers,and 4 were infiltrative.The diameter of the mass is measured to be 1.4-16.8 cm.The tumors of 13 patients originated in the stomach,and the diseases of the other 17 patients originated in the intestines.Clinicopathological analysis results showed that 8 cases were low-grade malignant,and the remaining 22 cases were high-grade malignant,with small/medium tumor cells,irregular,dense and deep stained nuclei.The immunohistochemical staining was applied to the tissue samples of 16 patients,including 15 cases of B-cell lymphoma.Thirteen of them were revisited,and 10 patients survived more than five years.Conclusion As one of the tumors with specific clinicopathological characteristics,the incidence of gastrointestinal mucosa-associated lymphoid tissue lymphoma may be related to HP infection.It is mainly derived from B lymphocytes.Compared with gastrointestinal cancer,MALT lymphoma has a higher prognosis.
作者
金笛
桑占发
JIN Di;SANG Zhanfa(Department of Pathology,79th Army Hospital of the Chinese People's Liberation Army,Liaoyang 111000,China)
出处
《中国医药指南》
2022年第20期81-84,共4页
Guide of China Medicine
关键词
胃肠黏膜
相关淋巴组织
淋巴瘤
临床病理
病变位置
免疫组化染色
Gastrointestinal mucosa
Related lymphoid tissues
Lymphoma
Clinicopathology
Lesion location
Immunohistochemical staining
