摘要
目的探讨改良亚冬眠疗法联合更昔洛韦治疗对病毒性脑炎患儿意识恢复及血清、脑脊液生化指标的影响。方法2018年6月-2020年2月在邢台市人民医院儿三科诊断为除巨细胞病毒(CMV)、日本乙型脑炎病毒(JEV)、麻疹病毒(MeV)、水痘带状疱疹病毒(VZV)、单纯疱疹病毒1型(HSV-1)、单纯疱疹病毒2型(HAV-2)外感染的病毒性脑炎患儿119例,按照随机数字法将患者分为研究组(61例)和对照组(58例)。所有患者给予更昔洛韦及对症支持治疗,对照组在此基础上加用亚冬眠疗法治疗,研究组患者加用改良亚冬眠疗法治疗。比较两组患者症状消失时间、疗效、不良反应、住院时间、治疗费用,及血清和脑脊液生化指标。结果治疗总有效率研究组为96.72%,对照组为79.31%,差异有统计学意义(P<0.05);研究组患者症状消失时间、总住院时间均短于对照组(均P<0.05);两组患者总治疗费用差异无统计学意义(P>0.05);治疗后,两组患者NSE、S-100β、NGF、hs-CRP水平均低于治疗前(均P<0.05),但研究组患者上述指标均低于对照组(均P<0.05);治疗后,两组患者LDH、CK、单核细胞数、蛋白定量、总细胞数水平均低于治疗前(P<0.05),但研究组患者上述指标均低于对照组(均P<0.05);两组患者总不良反应率差异无统计学意义(P>0.05)。结论改良亚冬眠疗法联合更昔洛韦可提高小儿病毒性脑炎疗效,改善NSE、S-100β、NGF、hs-CRP、LDH、CK、脑脊液单核细胞数、蛋白定量、总细胞数水平,减少住院时间,加快症状消失时间。且改良亚冬眠疗法对已知病毒性脑炎患儿的治疗同样具有意义。
Objective To investigate the effects of modified subhibernation therapy combined with ganciclovir on consciousness recovery,serum and cerebrospinal fluid biochemical indexes in children with viral encephalitis.Methods A totle of 119 children,who were diagnosed as viral encephalitis excepting infection of cytomegalovirus(CMV),Japanese encephalitis virus(JEV),Measles virus(MeV),varicella zoster virus(VZV),herpes simplex virus type 1(HSV-1),herpes simplex virus type 2(HSV-2)by the third department of paediatrics in Xingtai People’s Hospital from June 2018 to February 2020,were divided into the control group(n=61)and study group(n=58)according to random number table methods.All patients received ganciclovir and symptomatic support therapy,based on this,the control group received subhibernation therapy,and the study group received modified subhibernation therapy depending on the half-life of the drug for administration.The symptoms disappearance time,curative effect,adverse reactions,hospitalization time and treatment cost were compared between groups.The serum biochemical indexes were detected by enzyme-linked immunosorbent assay,and cerebrospinal fluid biochemical indexes were detected by fully automatic biochemical analyser,both were compared between groups.Results The total effective rate of study group was 96.72%,which was significantly higher than that of control group(79.31%)(P<0.05).After treatment,the levels of NSE,S-100β,NGF,and hs-CRP were significantly decreased in both groups(P<0.05).Conclusion Modified subhibernation therapy combined with ganciclovir can improve the curative effect of viral encephalitis in children,which can improve the levels of NSE,S-100β,NGF,hs-CRP,LDH,CK,mononuclear cell number,protein quantification and total cell number,reduce the hospitalization time,and accelerate the disappearance of symptoms.Moreover,the modified subhibernation therapy also has therapeutic significance for children with encephalitis infected by known viruses.
作者
韩冰
赵丽静
回立远
秦校芳
王芳
刘伟霄
HAN Bing;ZHAO Li-jing;HUI Li-yuan;QIN Xiao-fang;WANG Fang;LIU Wei-xiao(Department of Paediatrics,Xingtai People’s Hospital,Xingtai,Hebei 054000,China;Department of Neurology,The Second Hospital of Xingtai Medical College;Department of Neonatology,Xingtai Third Hospital;Emergency Department,Xingtai People’s Hospital)
出处
《中国病原生物学杂志》
CSCD
北大核心
2022年第5期586-590,共5页
Journal of Pathogen Biology
基金
河北省2019年度医学科学研究课题计划项目(No.20191709)。
关键词
改良亚冬眠疗法联合更昔洛韦
小儿病毒性脑炎
意识恢复
生化指标
modified subhibernation therapy combined with ganciclovir
viral encephalitis in children
consciousness recovery
serum and biochemical indexes
