摘要
情绪障碍相关疾病在青少年中的发病率逐年增加,给青少年的身心健康带来了极大伤害,甚至可持续影响至成年,然而其发病机制尚未完全阐明。默认模式网络(default mode network,DMN)是大脑在静息状态下仍活跃的脑区所组成的脑网络。DMN是静息态脑功能研究领域的热点,但少有研究关注其在青少年情绪障碍相关疾病下的病理变化。近几年发表的多篇与青少年情绪障碍疾病相关的文章,从影像学角度为理解青少年情绪障碍特征及其潜在机制提供了线索。本文将近年来相关研究进行总结后发现,青少年情绪障碍的发生与DMN脑区激活、皮质厚度、灰质体积或密度以及脑区之间功能连接变化密切相关,部分脑结构和功能改变可作为预测因素。本文通过归纳这些情绪障碍疾病脑影像学的改变,以期探究新的神经影像学标志性改变,为青少年情绪障碍相关疾病的预防、诊断及治疗提供理论依据。
The incidence of emotion disability-related diseases in adolescents is increasing year by year,causing great harm to their physical and mental health,even affecting them until adulthood.However,the mechanism of this has not been fully clarified.The default mode network is a brain network composed of brain regions that are still active in the resting state.DMN is a hot pot in the field of resting state brain function research,but few studies have focused on its pathological changes in the adolescents with emotion disability-related diseases.In recent years,a number of articles related to adolescent emotion disorders have provided clues for understanding the characteristics and potential mechanisms of adolescent emotion disorders from the perspective of imaging.This paper summarized the related research over the years and found that the occurrence of emotion disorders is closely related to the activation of the default mode network brain regions,cortical thickness,gray matter volume or density,and changes in functional connections between brain areas.Some changes in brain structure and function can be used as predictive factors.In this paper,by summarizing the changes in brain imaging of these emotion disorders,we hope to explore new neuroimaging landmark changes,which can provide theoretical basis for the prevention,diagnosis and treatment of emotion disorders related diseases in adolescents.
作者
徐璇
黄瑜琳
马正良
Xu Xuan;Huang Yulin;Ma Zhengliang(Department of Anesthesiology,Drum Tower Hospital Affiliated to Nanjing University Medical School,Nanjing 210008,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2022年第6期566-570,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金(81971044)。
关键词
青少年
情绪障碍
默认模式网络
Adolescent
Emotion disorder
Default mode network
