摘要
目的 探究酸激酶同工酶(CK-MB)、C-反应蛋白(CRP)及半胱氨酸蛋白酶抑制剂C(CysC)在重症肺炎中的表达及与心力衰竭的关系。方法 选取2018年3月至2021年1月首都医科大学附属北京世纪坛医院收治的98例重症肺炎患者作为研究组,并根据患者是否合并心力衰竭分为心力衰竭组(n=31)和非心力衰竭组(n=67)。另选取同期健康体检的89例健康志愿者设为对照组。比较不同人群CK-MB、CRP及CysC表达水平;分析CK-MB、CRP及CysC表达对重症肺炎患者并发心力衰竭的预测价值。结果 研究组CK-MB、CRP及CysC水平明显高于对照组,差异具有统计学意义(P<0.05)。心力衰竭组CK-MB、CRP及CysC水平明显高于非心力衰竭组,差异具有统计学意义(P<0.05)。ROC曲线分析结果显示,CK-MB、CRP、CysC三者联合检测对重症肺炎患者并发心力衰竭预测价值的AUC更高,为0.918(0.859~0.977)(P<0.05)。结论 CK-MB、CRP及CysC在重症肺炎并发心力衰竭患者中表达均明显上调,提示临床可通过检测三者水平对重症肺炎患者并发心力衰竭的事件进行预测及诊断。
Objective To explore the expression of Creatine kinase isoenzyme(CK-MB),C-reactive protein(CRP)and cystatin C(CysC)in patients with severe pneumonia and their relationship with heart failure. Methods 98 patients with severe pneumonia who were treated in Beijing Shijitan Hospital,Capital Medical University from March 2018 to January 2021 were retrospectively collected as the study group.The patients were divided into the heart failure group(n=31)and the non-heart failure group(n=67)according to whether they had heart failure or not. In addition,89 health volunteers underwent health checkups during the same time were set as the control group. The expression levels of CK-MB,CRP and CysC in different groups were compared. The predictive values of CK-MB,CRP and CysC expression in patients with severe pneumonia complicated by heart failure were analyzed. Results The levels of CK-MB,CRP,and CysC in the study group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05). The levels of CK-MB,CRP and CysC in the heart failure group were significantly higher than those in the non-heart failure group,and the difference was statistically significant(P<0.05). The results of ROC curve analysis showed the CK-MB,CRP and CysC combined detection CK-MB,CRP and CysC had a higher AUC of 0.918(0.859-0.977)(P<0.05)for the predictive value of patients with severe pneumonia complicated by heart failure. Conclusion The expressions of CK-MB,CRP and CysC are significantly up-regulated in patients with severe pneumonia complicated by heart failure,suggesting that clinical detection of the three levels can be used to predict and diagnose the events of severe pneumonia complicated by heart failure.
作者
王宇锬
李悠然
朱宇
赵石洋
WANG Yutan;LI Youran;ZHU Yu;ZHAO Shiyang(Department of Emergency,Beijing Century Altar Hospital Affiliated to Capital Medical University,Beijing,China,100038;Department of Critical Care Medicine,the Fourth Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,China,150001;Department of Cardiovascular Surgery,the Fourth Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,China,150001;Department of Radiology,924 Hospital of PLA Joint Logistics Support Force,Guilin,Guangxi,China,541001)
出处
《分子诊断与治疗杂志》
2022年第7期1137-1140,共4页
Journal of Molecular Diagnostics and Therapy
基金
北京市自然科学基金资助项目(7204236)。
