摘要
目的研究右美托咪定帕金森病患者DBS术后的谵妄发生率和对认知能力的影响。方法选择2019年10月到2020年7月间接受DBS手术的70名帕金森病患者。随机分为盐水对照组和观察组各35例,谵妄量表(CAM-CR)、简易精神状态评价量表(MMSE)和蒙特利尔认知评价量表(MoCA)对两组患者的术前术进行比较后的谵妄发生率和认知水平的变化进行评价。结果术后1d两组患者MMSE评价没有明显的差异(P>0.05),术后3d,观察组CAM-CR和MoCA评分显著下降,MMSE评价显著提高,谵妄的发生率也显著降低(P<0.05)。结论右美托咪定可以降低DBS术后的谵妄发生率,且能明显改善术后认知能力损伤。
Objective To investigate the incidence of delirium and its effect on cognitive ability after DBS with dexmedetomidine in patients with Parkinson's disease.Methods Seventy Parkinson's disease patients who underwent DBS surgery between October 2019 and July 2020 were selected.Randomly divided into saline control group and observation group,35 cases in each group.The incidence of delirium and changes in cognitive level were evaluated after comparison.Results There was no significant difference in the MMSE evaluation between the two groups on the 1st day after the operation(P>0.05).On the 3rd day after the operation,the CAM-CR and MoCA scores of the observation group were significantly decreased,the MMSE evaluation was significantly improved,and the incidence of delirium was also significantly decreased(P<0.05).Conclusion Dexmedetomidine can reduce the incidence of delirium after DBS,and can significantly improve postoperative cognitive impairment.
作者
麻黎斯
司马靓杰
苗亚飞
任岩岩
聂建圳
MA Li-si;SIMA Liang-jie;MIAO Ya-fei;REN Yan-yan;NIE Jian-zhen(Department of Anesthesiology,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan Province,China;Operating Room,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan Province,China)
出处
《罕少疾病杂志》
2022年第8期16-18,共3页
Journal of Rare and Uncommon Diseases
关键词
帕金森病
DBS术后认知障碍
右美托咪定
Parkinson's Disease
Cognitive Impairment after DBS
Dexmedetomidine
