摘要
采用动、静态结合的方法,以头孢羟氨苄为模型药物,在超临界二氧化碳(ScCO_(2))中测定其溶解度。分别在温度为308,313,318 K,压力为10,12,14,16 MPa条件下,测试头孢羟氨苄在有、无共溶剂(乙醇)时的溶解度,并对测试结果应用半经验模型进行关联。结果表明:当温度一定时,药物在ScCO_(2)中的溶解度随压力升高而增大;而温度对溶解度影响较为复杂,在12—14 MPa之间存在压力转折点(PTP)。当压力小于PTP时,高温不利于提高溶解度;当压力大于PTP时,同一压力下随着温度升高,药物溶解度也明显提高。研究还发现共溶剂的加入会提高药物的溶解度。半经验模型拟合的溶解度理论数值与实验测得数值也基本接近,当不含共溶剂时,与K-J模型关联效果最好,平均相对偏差为16.50%;含共溶剂时,与T-G模型关联情况最好,平均相对偏差为9.44%。
The solubility of cefadroxil as a model drug in supercritical carbon dioxide(ScCO_(2))was determined by combination of dynamic and static methods.The solubility of cefadroxil in the presence and absence of cosolvent(ethanol)was tested at 308,313 and 318 K and 10,12,14 and 16 MPa,respectively,and the test results were correlated by semi-empirical model.The results show that when the temperature is constant,the solubility increases with the increase of pressure.The effect of temperature on solubility is complex,and there is a pressure turning point(PTP)between 12-14 MPa.When the pressure is less than PTP,high temperature is not conducive to improving the solubility.When the pressure is greater than PTP,the solubility increases significantly with the increase of temperature at the same pressure.It was also found that the addition of cosolvent could improve the solubility of the drug.The theoretical values of solubility fitted by the semi empirical model are also basically close to the experimental values.When there is no cosolvent,the correlation effect of K-J model is the best,and the average relative deviation is 16.50%.When the cosolvent is included,the correlation of T-G model is the best,and the average relative deviation is 9.44%.
作者
王振宇
于驰
刘蒙蒙
李帅
詹世平
WANG Zhen-yu;YU Chi;LIU Meng-meng;LI Shuai;ZHAN Shi-ping(School of Environmental and Chemical Engineering,Dalian University,Dalian 116622,Liaoning Province,China)
出处
《化学工程》
CAS
CSCD
北大核心
2022年第6期50-55,78,共7页
Chemical Engineering(China)
基金
国家自然科学基金资助项目(41606001)。
