摘要
人类基因组中大约有1000个膜转运体编码基因,溶质载体蛋白(SLCs)为其中最大的转运蛋白群。SLC25A51(一种功能未知的重要线粒体蛋白,也被称为MCART1)即为SLCs转运蛋白家族中一员。SLC25A51在能量代谢中发挥着重要作用,不仅肩负哺乳动物线粒体中烟酰胺腺嘌呤二核苷酸(NAD~+)转运蛋白的重任,而且直接介导哺乳动物线粒体NAD~+池的生成。现有研究证实,在酵母和植物的线粒体中存在NAD~+转运体,而最新研究发现在哺乳动物线粒体中也存在NAD~+转运体。现对SLC25A51的作用机制及其与心血管疾病的发生发展关系做一综述。
There are about 1000 membrane transporters encoding genes in the human genome,and solute carrier proteins(SLCs)are the largest transporter group.SLC25A51(an important mitochondrial protein with unknown function,also known as MCART1)is a member of the SLCs transporter family.SLC25A51 plays an important role in energy metabolism,not only carrying the responsibility of nicotinamide adenine dinucleotide(NAD+)transporter in mammalian mitochondria,but also directly mediating the formation of mammalian mitochondrial NAD+pool.NAD+transporters have been confirmed in mitochondria of yeast and plants,and the latest study found that NAD+transporters also exist in mammalian mitochondria.This article reviews the mechanism of SLC25A51 and the relationship between SLC25A51 and the occurrence and development of cardiovascular diseases.
作者
柴贞
王建民
王霞飞
王昱
牛晨光
滕伟
CHAI Zhen;WANG Jianmin;WANG Xiafei;WANG Yu;NIU Chenguang;TENG Wei(Department of Cardiology,The First Affiliated Hospital of Henan University,Kaifeng 475000,China;The First Affiliated Haspital of Henan University,Kaifeng 475000,China)
出处
《中国分子心脏病学杂志》
CAS
2022年第2期4596-4599,共4页
Molecular Cardiology of China
