摘要
目的调查热带海岛人群中高尿酸血症的流行情况, 分析高尿酸血症及痛风患者并发泌尿系结石的危险因素。方法选取接受年度体检的638例热带海岛人群样本作为研究对象, 收集一般资料、肾功能指标及泌尿系超声检查资料, 采用组间对比及Logistic回归方法进行统计学分析。结果热带海岛人群的高尿酸血症发生率为36.4%, 痛风发生率为1.3%。泌尿系结石在尿酸正常、单纯高尿酸血症和痛风人群中的发生率分别为14.3%、23.9%和72.7%。人群中肌酐与尿酸水平呈正相关(r=0.25, P<0.001), 而尿素氮随着尿酸的升高而略有上升(r=0.07, P=0.051)。血尿酸升高(OR=1.0, P=0.013)和痛风发作史(OR=7.9, P=0.004)是热带海岛人群发生泌尿系结石的危险因素, 两者联合预测泌尿系结石发生的ROC曲线下面积(AUC)为0.601, 略高于血尿酸水平单独预测时的0.598(P=0.158)。结论热带海岛人群中尿酸异常升高比例显著高于其他地区人群, 且肌酐和尿素氮水平变化与尿酸水平变化呈正相关。血尿酸升高和痛风发作史是热带海岛人群发生泌尿系结石的危险因素, 两指标联合应用对于泌尿系结石的发生具有一定预测性。
Objective To investigate the prevalence of hyperuricemia in tropical island population,and to analyze the risk factors of urinary calculi in patients with hyperuricemia or gout.Methods A total of 638 samples of tropical island people who received annual physical examinations were the subjects of our study.Their general information,renal function indicators,and urological ultrasound data were collected.The intergroup comparison and binary Logistic regression were applied for statistical analysis.Results The incidences of hyperuricemia and gout were 36.4%and 1.3%,respectively,in tropical island population.The incidences of urinary calculi in cases with normal uric acid,asymptomatic hyperuricemia,and gout were 14.3%,23.9%,and 72.7%,respectively.A positive correlation was found between serum creatinine and uric acid levels among the 638 cases(r=0.25,P<0.001),and the level of urea nitrogen increased slightly with the increase of uric acid(r=0.07,P=0.051).The elevated serum uric acid(OR=1.0,P=0.013)and history of gout(OR=7.9,P=0.004)were risk factors for the occurrence of urinary calculi in tropical island population.The combination of these two parameters could predict the occurrence of urinary calculi with AUC=0.601,which was slightly better than using serum uric acid level alone with AUC=0.598(P=0.158).Conclusion The proportion of patients with hyperuricemia in tropical islands is significantly higher than that in non-tropical regions.The serum creatinine and urea nitrogen levels are positively correlated with uric acid levels among the cases.The elevated serum uric acid and history of gout are risk factors for the occurrence of urinary calculi in tropical island population.The combination of these two parameters has a certain role in predicting the occurrence of urinary calculi.
作者
张威
杨宾
李浩维
施晓磊
叶宸
刘曼娇
Zhang Wei;Yang Bin;Li Haowei;Shi Xiaolei;Ye Chen;Liu Manjiao(Department of Urinary Surgery,The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China;Department of Urinary Surgery,PLA Navy No.929 Hospital,Shanghai 200433,China;Department of Ultrasound Diagnosis,PLA Navy No.929 Hospital,Shanghai 200433,China;Department of Pathology and Blood Transfusion,PLA Navy No.929 Hospital,Shanghai 200433,China)
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2022年第2期172-176,共5页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
基金
海军军医大学启航人才项目(2021)。
