摘要
Oncolytic viruses(OVs)are emerging as potentially useful platforms in treatment methods for patients with tumors.They preferentially target and kill tumor cells,leaving healthy cells unharmed.In addition to direct oncolysis,the essential and attractive aspect of oncolytic virotherapy is based on the intrinsic induction of both innate and adaptive immune responses.To further augment this efficacious response,OVs have been genetically engineered to express immune regulators that enhance or restore antitumor immunity.
基金
This work was supported by the National Natural Science Foundation of China(NSFC)under grant No.82073366
by the National Major Scientific and Technological Special Project for“Significant New Drugs Development”under grant No.2018ZX09201018-013
by the Talents project of Sichuan University of Science&Engineering under grant number E10402637.
