摘要
A rhodium-catalyzed[4+3]cycloaddition reaction between N-methoxybenzamides and gem–difluorocyclopropenes is described.The reaction offers a mild and efficient approach towards the synthesis of fluorinated 2 H-azepin-2-ones with broad substrate scope.A consecutive HOAc-assisted C–N bond formation and fluorine elimination are involved as key steps for success as illustrated by detailed DFT studies.
基金
National Natural Science Foundation of China(Nos.21861007,21702034)
Natural Science Foundation of Guangxi Province(No.2021GXNSFAA075024)
“BAGUI Scholar”Program of Guangxi Province of China
High-Level Innovation Team and Distinguished Scholar Program in Guangxi Colleges and Universities。