摘要
角膜病是全球最重要的致盲性眼病之一,所导致的角膜混浊严重损害视功能,如发生角膜溃疡可导致穿孔,甚至可丧失眼球。尽管角膜移植是临床上常规的治疗方法,但我国不仅角膜供体严重缺乏,与临床需求差距巨大,同时移植手术后的各类并发症难以避免。近年来,随着再生医学的飞速发展,人们发现间充质干细胞在适宜的诱导条件下可以分化为包括角膜组织在内的多种功能细胞,具有广阔的临床应用前景,在诸多方面为角膜病治疗和角膜盲复明提供新的思路和方法。本文旨在对间充质干细胞在各学科的诱导方法及角膜方面的研究状况进行综述。
Keratopathy is one of the most important blinding eye diseases in the world.Corneal opacity caused by keratopathy can seriously damage visual function.For example,corneal ulcer can lead to perforation and even loss of the eyeball.Although corneal transplantation is a routine treatment in clinical practice,there are not only a serious shortage of corneal donors in our country,but also various complications after keratoplasty that can not be avoided.In recent years,with the rapid development of regenerative medicine,it has been found that mesenchymal stem cells can differentiate into a variety of functional cells including corneal tissue under suitable induction conditions,which has a broad prospect of clinical application.This finding provides new ideas and methods for the treatment of keratopathy and corneal blindness in many aspects.This article reviews the research status of induction methods of mesenchymal stem cells in various specialties,particularly in the corneal subspecialty.
作者
刘晶劼
王丽强
黄一飞
Liu Jingjie;Wang Liqiang;Huang Yifei(The Ophthalmology Division of Chinese PLA General Hospital,Beijing 100853,China)
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2022年第6期461-466,共6页
Chinese Journal of Ophthalmology
基金
新型材料仿生化技术再生修复战创伤的应用研究项目(BLB20J011)。
关键词
角膜
间质干细胞
细胞分化
再生
Cornea
Mesenchymal stem cells
Cell ifferentiation
Regeneration
