摘要
序贯免疫接种是在当前COVID-19疫情严重时期,解决疫苗短缺、应对新型冠状病毒突变、提高疫苗效力的特殊手段之一。本文以世界卫生组织授权的新型冠状病毒疫苗(新冠疫苗)为主,就目前采用灭活疫苗初次免疫+重组蛋白疫苗/载体疫苗/mRNA疫苗加强免疫、载体疫苗初次免疫+mRNA疫苗加强免疫,以及不同剂型的mRNA疫苗互为初次和加强免疫的5种新冠疫苗序贯免疫接种方式的研究和临床试验进行综述。多项研究结果表明,异源序贯接种策略安全有效,接种者获得的免疫原性和有效性超出其中任何一种疫苗的同源接种,且在对抗新型冠状病毒变异株方面也有一定的效力。
Sequential immunization is one of the special means to solve the shortage of vaccines,respond to SARS-CoV-2 variants and improve the efficacy of vaccines in the current pandemic period.This article mainly reviewed five sequential immunization strategies using the vaccines authorized by World Health Organization:priming with inactivated vaccine and boosting with recombinant protein vaccine,vector vaccine or mRNA vaccine;priming with vector vaccine and boosting with mRNA vaccine;prime-boost immunization with mRNA vaccines produced by different manufactures.Results of the related studies showed that heterologous sequential immunization strategies were safe and effective,and higher immunogenicity and efficacy could be achieved by sequential immunization.In addition,sequential immunization could provide certain protective effects against SARS-CoV-2 variants.
作者
宋卫卫
徐强
柯尊阳
邱创钧
李忠明
王宇
Song Weiwei;Xu Qiang;Ke Zunyang;Qiu Chuangjun;Li Zhongming;Wang Yu(Research and Development Center,Gu′an Dingtai Haigui Biotechnology Co.,Ltd.,Langfang 065500,China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2022年第6期456-463,共8页
Chinese Journal of Microbiology and Immunology
